An overdose of paracetamol is dangerous and capable of causing serious damage to the liver and kidneys. Never exceed the recommended dose of Lemsip max flu lemon. Get immediate medical advice in the event of an overdose with this medicine, even if you feel well, because of the risk of delayed, serious liver damage. Because of its low risk of causing allergic reactions, this drug can be administered in patients who are intolerant to salicylates and those with allergic tendencies, including bronchial asthmatics. Specific dosing guidelines should be followed when administering acetaminophen to children.

Long-term studies in mice and rats have been completed by the National Toxicology Program to study the carcinogenic risk of acetaminophen. In 2-year feeding studies, F344/N rats and B6C3F1 mice consumed a diet containing acetaminophen up to 6,000 ppm. Female rats showed evidence of carcinogenic activity demonstrated by a higher incidence of mononuclear cell leukemia at doses 0.8 times the maximum human daily dose (MHDD). No evidence of carcinogenesis in male rats (0.7 times) or mice (1.2 to 1.4 times the MHDD) was noted. The clinical relevance of this finding in humans is unknown. Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with the ingredients of Lemsip cough max for mucus cough and cold. Just because a side effect is stated here doesn't mean that all people using this medicines will experience that or any side effect. Meanwhile, certain people should get medical advice before taking Lemsip cough max for mucus cough and cold. They include people with any of the following symptoms, as the cough should be investigated further: Lemsip overdose may be manifested by renal tubular necrosis, hypoglycemic coma, and thrombocytopenia. Sometimes, liver necrosis can occur as well as liver failure. Death and the requirement of a liver transplant may also occur. Metabolism by the CYP2E1 pathway releases a toxic acetaminophen metabolite known as N-acetyl-p-benzoquinoneimine(NAPQI). The toxic effects caused by this drug are attributed to NAPQI, not acetaminophen alone.The medicine comes as capsules and sachets for making hot drinks. Both are licensed for adults and adolescents aged 12 years and over. It's not known if phenylephrine passes into breast milk, or its effect on a nursing infant. When taken by mouth, decongestants such as phenylephrine can also temporarily decrease the production of breast milk with just one or two doses. Lemsip max should not be used by woman who are breastfeeding. Ask your doctor or pharmacist for further advice. Lemsip max cold and flu capsules should be used with caution in: This is the case both for medicines prescribed by a doctor and for medicines you buy from a pharmacy or shop. Which medicines are safe? Alcohol increases the risk of liver damage that can occur if an overdose of paracetamol is taken. The hazards of paracetamol overdose are greater in persistent heavy drinkers and in people with alcoholic liver disease. Empty the contents of the sachet into a cup. Add half a cup of hot (not boiling) water and stir to dissolve. You can add cold water and sugar if you want before drinking.

A wealth of other cold and flu remedies are available to buy without a prescription. Many of these will also contain paracetamol or pseudoephedrine in their ingredients. An overdose of paracetamol is dangerous and capable of causing serious damage to the liver and kidneys. Get immediate medical advice if you or someone you know takes too much paracetamol, even if you feel well, because of the risk of delayed, serious liver damage. Paracetamol is generally considered safe for use during pregnancy. However, the safety of pseudoephedrine has not been established and some studies have suggested that use of pseudoephedrine in the first trimester may be associated with defective closure of the abdominal wall (gastroschisis) in the baby. As a result, Lemsip max flu lemon is not usually recommended for use by women who are pregnant. Get further medical advice from your doctor, pharmacist or midwife. talk to your doctor immediately if you take regular medicine, ideally before you start trying for a baby or as soon as you find out you're pregnant Do not take more than the recommended dose. You should also avoid taking more than one paracetamol-containing medicine at the same time, as this can easily result in exceeding the maximum dose of paracetamol.

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Whelton PK, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension. 2018; doi:10.1161/HYP.0000000000000065. The antidiabetic medicines exenatide, lixisenatide and liraglutide may slow down the absorption of paracetamol into the bloodstream, so it might take longer to work if you're using one of these medicines to treat your diabetes. Ask your pharmacist for more advice.

Consider pain medicine carefully. Use aspirin or acetaminophen to treat a fever, sore throat, headache or body aches. Do not take nonsteroidal anti-inflammatory drugs (NSAIDs). They may lead to high blood pressure. Examples of NSAIDs are ibuprofen (Motrin IB, Advil) and The Professional Standards Authority for Health and Social Care (PSA) provides information on qualified or registered practitioners. Avoid taking Lemsip max flu lemon if you're already taking any of the following medicines because the combination may increase your blood pressure:

Toxicity

The antidiabetic medicines exenatide, lixisenatide and liraglutide may slow down the absorption of paracetamol into the bloodstream, so Lemsip max flu lemon might take longer to work if you are using one of these medicines to treat your diabetes. Ask your pharmacist for more advice. Lemsip is often found combined with other drugs in more than 600 over the counter (OTC) allergy medications, cold medications, sleep medications, pain relievers, and other products. Confusion about dosing of this drug may be caused by the availability of different formulas, strengths, and dosage instructions for children of different ages. Due to the possibility of fatal overdose and liver failure associated with the incorrect use of acetaminophen, it is important to follow current and available national and manufacturer dosing guidelines while this drug is taken or prescribed. Women who are pregnant. Phenylephrine has blood vessel constricting effects that could restrict blood supply to the placenta, or cause problems for women with a history of pre-eclampsia. Ask your doctor or pharmacist for further advice on how to treat cold and flu symptoms during pregnancy. Adults and adolescents aged 16 years and over should take one sachet every four to six hours as necessary, up to a maximum of four sachets in 24 hours.

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that may be associated with pseudoephedrine and paracetamol. Just because a side effect is stated here doesn't mean that all people taking Lemsip max flu lemon will experience that or any side effect. The capsules should be swallowed whole with a drink. They can be taken either with or without food. Paracetamol is thought to relieve pain by reducing the production of prostaglandins in the brain and spinal cord. It works to bring down a fever by affecting an area of the brain that regulates our body temperature (the hypothalamic heat-regulating center). This stops you feeling hot or shivery.

If you're taking medicines for high blood pressure you shouldn't take Lemsip max flu lemon as well, because the pseudoephedrine may make your blood pressure medicine less effective.