In particular, devil’s claw contains iridoid glycosides, a class of compounds which has demonstrated anti-inflammatory effects ( 2). Brien, S., Lewith, G. T., and McGregor, G. Devil's Claw (Harpagophytum procumbens) as a treatment for osteoarthritis: a review of efficacy and safety. J Altern Complement Med 2006;12(10):981-993. View abstract. Moussard C, Alber D, Toubin MM, et al. A drug used in traditional medicine, harpagophytum procumbens: no evidence for NSAID-like effect on whole blood eicosanoid production in human. Prostaglandins Leukot Essent Fatty Acids. 1992;46:283-6.. View abstract. Schulze-Tanzil, G., Hansen, C., and Shakibaei, M. [Effect of a Harpagophytum procumbens DC extract on matrix metalloproteinases in human chondrocytes in vitro]. Arzneimittelforschung. 2004;54:213-220. View abstract. Chrubasik S, Sporer F, Dillmann-Marschner R, et al. Physicochemical properties of harpagoside and its in vitro release from Harpagophytum procumbens extract tablets. Phytomedicine 2000;6:469-73. View abstract.

Ficarra P, Ficarra R, Tommasini A, and et al. [HPLC analysis of a drug in traditional medicine: Harpagophytum procumbens DC. I]. Boll Chim Farm 1986;125(7):250-253. There are also specific exercises that you can do. Walking, swimming, yoga and pilates can be helpful, and exercises that help with posture, muscle tone, balance, and joint mobility can help in both the short and long term, while also potentially relieving stress and tension.

What’s the history of devil’s claw?

Schendel, U. Arthritis treatment: Study with Devil Claw extract [in German]. Der Kassenarzt 2001;29/30:2-5.

Atrosan ® tablets contain an extract of Devil’s Claw, which is not associated with any addictive properties. There are no reports of addiction with this product and it is not something that we would expect to see with use of Devil’s Claw. Belaiche P. Etude clinique de 630 cas d'artrose traites par le nebulisat aqueux d'Harpagophytum procumbens (Radix). Phytotherapy 1982;1:22-28. Betancor-Fernandez, A., Perez-Galvez, A., Sies, H., and Stahl, W. Screening pharmaceutical preparations containing extracts of turmeric rhizome, artichoke leaf, devil's claw root and garlic or salmon oil for antioxidant capacity. J Pharm Pharmacol 2003;55:981-986. View abstract.Brendler T. Review of devil's claw ( Harpagophytum spp.). Pharmaceuticals (Basel). 2021;14(8):726. doi: 10.3390%2Fph14080726 Clarkson, C., Campbell, W. E., and Smith, P. In vitro antiplasmodial activity of abietane and totarane diterpenes isolated from Harpagophytum procumbens (devil's claw). Planta Med 2003;69:720-724. View abstract.

This is not an all-inclusive list of medication interactions. To be on the safe side, always discuss your use of supplements with your doctor. Summary Erdos, A., Fontaine, R., Friehe, H., Durand, R., and Poppinghaus, T. [Contribution to the pharmacology and toxicology of different extracts as well as the harpagosid from Harpagophytum procumbens DC]. Planta Med 1978;34:97-108. View abstract. Chrubasik S, Sporer F, and Wink M. [Content of active substance in tea preparations from Harpagophytum procumbens]. Forsch Komplementarmed 1996;3:116-119.

Whitehouse LW, Znamirowska M, Paul CJ. Devil's Claw (Harpagophytum procumbens): no evidence for anti-inflammatory activity in the treatment of arthritic disease. Can Med Assoc J 1983;129:249-51. View abstract. Spelman, K., Burns, J., Nichols, D., Winters, N., Ottersberg, S., and Tenborg, M. Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. Altern.Med.Rev. 2006;11(2):128-150. View abstract. Schulze-Tanzil, G., Hansen, C., and Shakibaei, M. [Effect of a Harpagophytum procumbens DC extract on matrix metalloproteinases in human chondrocytes in vitro]. Arzneimittelforschung. 2004;54(4):213-220. View abstract.