Ibraheem W, Jedaiba WH, Alnami AM, et al. Efficacy of hyaluronic acid gel and spray in healing of extraction wound: a randomized controlled study. Eur Rev Med Pharmacol Sci. 2022;26(10):3444-3449. doi:10.26355/eurrev_202205_28838

Kim JS, Lee SS, Kim TJ, Park YW. Serum hyaluronic acid levels do not explain morning stiffness in patients with fibromyalgia. Clinical Rheumatology. 2010;29(5):535-539. doi:10.1007/s10067-010-1372-z Gingivitis (gum disease): A double-blind parallel three-arm (0.12% chlorhexidine, 0.025% HA, and a water-based antioxidant mouthwash containing beta-carotene and vitamin E and C as active ingredients) clinical trial was conducted in 75 people 18 to 23 years with biofilm-induced gingivitis. It showed that all three interventions significantly reduced the plaque index (PI) after seven days compared to the baseline data. However, chlorhexidine showed a larger PI reduction than the HA and antioxidant mouthwashes.Skin wrinkles: The typical HA dose for use in the setting of skin wrinkles is 120 milligrams (mg) HA capsule by mouth daily for 12 weeks. Although intradermal (within the skin) injection of HA has been studied in the field of esthetic dermatology, the effect of HA alone in serum-containing HA is unclear given that most products combine HA with other active ingredients (e.g., vitamins C and E) known to enhance skin health. Delivery is on a selected date, you can choose a delivery day of your choice, up to 10 days in advance (Excluding next day delivery. Postcode restrictions apply) Hsu TF, Su ZR, Hsieh YH, et al. Oral hyaluronan relieves wrinkles and improves dry skin: a 12-week double-blinded, placebo-controlled study. Nutrients. 2021;13(7):2220. doi:10.3390/nu13072220

Urinary tract infections: A study conducted in 10 children aged 2 to 18 years with spina bifida and neurogenic bladder who performed clean intermittent catheterization (a technique for bladder drainage) showed that the instillation of 40 milligrams (mg) HA into the bladder weekly for four weeks then monthly for the following three months reduced symptomatic recurrent urinary tract infections. However, further multicenter randomized, controlled clinical trials with larger sample sizes and longer follow-ups are needed to confirm such promising results. Marinho A, Nunes C, Reis S. Hyaluronic acid: a key ingredient in the therapy of inflammation. Biomolecules. 2021;11(10):1518. doi:10.3390/biom11101518‌ Gupta RC, Lall R, Srivastava A, Sinha A. Hyaluronic acid: molecular mechanisms and therapeutic trajectory. Frontiers in Veterinary Science. 2019;6. doi:10.3389/fvets.2019.00192 Jensen GS, Attridge VL, Lenninger MR, Benson KF. Oral intake of a liquid high-molecular-weight hyaluronan associated with relief of chronic pain and reduced use of pain medication: results of a randomized, placebo-controlled double-blind pilot study. Journal of Medicinal Food. 2015;18(1):95-101. doi:10.1089/jmf.2013.0174Yao ZY, Qin J, Gong JS, et al. Versatile strategies for bioproduction of hyaluronic acid driven by synthetic biology. Carbohydrate Polymers. 2021;264:118015. doi:10.1016/j.carbpol.2021.118015 Ingredients: Aqua (Water), Propylene Glycol, Betaine, Sodium Hyaluronate, Biosaccharide Gum-1, Caprylyl Glycol, Lactic Acid, Sodium Gluconate, Glycerin, Phenoxyethanol, Sodium Levulinate, Glyceryl Caprylate, Sodium Anisate, Xanthan Gum Singhal S, Hasan N, Nirmal K, et al. Bioavailable turmeric extract for knee osteoarthritis: a randomized, non-inferiority trial versus paracetamol. Trials. 2021;22(1). doi:10.1186/s13063-021-05053-7