Map showing the amount of opium produced in China in 1908: The quote "We English, by the policy we have pursued, are morally responsible for every acre of land in China which is withdrawn from the cultivation of grain and devoted to that of the poppy; so that the fact of the growth of the drug in China ought only to increase our sense of responsibility." is by Lord Justice Fry. Judis J: Binding of codeine, morphine, and methadone to human serum proteins. J Pharm Sci. 1977 Jun;66(6):802-6. [ Article] Opium – Poppy Cultivation, Morphine and Heroin Manufacture". Erowid.org . Retrieved January 25, 2017. Opium smoking began as a privilege of the elite and remained a great luxury into the early 19th century. However, by 1861, Wang Tao wrote that opium was used even by rich peasants, and even a small village without a rice store would have a shop where opium was sold. [47]

Julius Berendes (1902). "De Materia Medica" (in German). Archived from the original on February 8, 2007 . Retrieved May 10, 2007. John Lewis plc, registered office: 171 Victoria Street, London SW1E 5NN. Authorised and regulated by the Financial Conduct Authority (Register no. 724309) for the purpose of introducing the credit provided by Creation Consumer Finance Ltd, registered office: Wellington Buildings, 2-4 Wellington Street, Belfast BT1 6HT. Creation Consumer Finance Ltd is authorised and regulated by the Financial Conduct Authority (Register no. 311518). Peter Dale Scott, Asia-Pacific Journal Japan Focus, 1 Nov. 2010, Volume 8 | Issue 44 | Number 2, "Operation Paper: The United States and Drugs in Thailand and Burma" 米国とタイ・ビルマの麻薬

Both analgesia and drug addiction are functions of the mu opioid receptor, the class of opioid receptor first identified as responsive to morphine. Tolerance is associated with the superactivation of the receptor, which may be affected by the degree of endocytosis caused by the opioid administered, and leads to a superactivation of cyclic AMP signaling. [152] Long-term use of morphine in palliative care and the management of chronic pain always entails a risk that the patient develops tolerance or physical dependence. There are many kinds of rehabilitation treatment, including pharmacologically based treatments with naltrexone, methadone, or ibogaine. [153] Opium contains 50 different alkaloid opiates. The most common metabolism of opiates is to be ultimately converted to morphine which is further converted to morphine-3,6-diglucuronide. 16 Opioids are metabolized vastly by the enzyme CYP 2D6 and any mutation in this kind of enzyme or coadministration with drugs that interfere with this enzyme may generate a change in the metabolism speed. 18 For years, because of this metabolism pathway, it was very hard to differentiate between illicit heroin users and involuntary exposure to poppy seeds. The original tests for this differentiations were based in the presence of morphine in urine without evidence of 6-monoacetylmorphine. Now it is known the presence of a glucuronide metabolite only in the consumption of heroin called ATM4G and this allows a clear differentiation of the consumption of illegal heroin and poppy seed ingestion. 6

Windle J (2013). " 'Harms Caused by China's 1906–17 Opium Suppression Intervention' " (PDF). International Journal of Drug Policy. 24 (5): 498–505. doi: 10.1016/j.drugpo.2013.03.001. PMID 23567100. Lomax, Elizabeth (1973). "The Uses and Abuses Of Opiates In Nineteenth-Century England". Bulletin of the History of Medicine. 47 (2): 167–176. ISSN 0007-5140. JSTOR 44447528. PMID 4584236 . Retrieved May 31, 2022. Hardening of Canadian attitudes toward Chinese opium users and fear of a spread of the drug into the white population led to the effective criminalization of opium for nonmedical use in Canada between 1908 and the mid-1920s. [92]In 2021, the International Agency for Research on Cancer concluded that opium is a Group 1 (sufficient evidence) human carcinogen, causing cancers of the larynx, lung, and urinary bladder. [154] Slang terms [ edit ] The earliest clear description of the use of opium as a recreational drug in China came from Xu Boling, who wrote in 1483 that opium was "mainly used to aid masculinity, strengthen sperm and regain vigor", and that it "enhances the art of alchemists, sex and court ladies". He also described an expedition sent by the Ming dynasty Chenghua Emperor in 1483 to procure opium for a price "equal to that of gold" in Hainan, Fujian, Zhejiang, Sichuan and Shaanxi, where it is close to the western lands of Xiyu. A century later, Li Shizhen listed standard medical uses of opium in his renowned Compendium of Materia Medica (1578), but also wrote that "lay people use it for the art of sex," in particular the ability to "arrest seminal emission". This association of opium with sex continued in China until the end of the 19th century. This is the extract or extrait of a fragrance and represents the scent in its purest form. This often creates a smooth and round texture, which is hard to achieve with the dilution represented in the other concentrations of fragrance. Karl A. Sporer, M.D. (April 6, 1999). "Acute Heroin Overdose". Annals of Internal Medicine. 130 (7): 584–590. doi: 10.7326/0003-4819-130-7-199904060-00019. PMID 10189329. S2CID 22949289. The first known cultivation of opium poppies was in Mesopotamia, approximately 3400 BCE, by Sumerians, who called the plant hul gil, the "joy plant". [11] [12] Tablets found at Nippur, a Sumerian spiritual center south of Baghdad, described the collection of poppy juice in the morning and its use in production of opium. [1] Cultivation continued in the Middle East by the Assyrians, who also collected poppy juice in the morning after scoring the pods with an iron scoop; they called the juice aratpa-pal, possibly the root of Papaver. [13] Opium production continued under the Babylonians and Egyptians.