Similar benefit after subsequent chemo cycles (odds ratio: 0.59; 95% CI = 0.46–0.76, p< .0001), although analysis of impact of preexisting peripheral neuropathy not performed in statistics for late peripheral neuropathy group

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Symptoms assessed at baseline and before every cycle of paclitaxel administration during outpatient care Seretny M., Currie G. L., Sena E. S., Ramnarine S., Grant R., MacLeod M. R.,...Fallon M. (2014). Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis. Pain, 155( 12), 2461–2470. 10.1016/j.pain.2014.09.020 [ PubMed] [ CrossRef] [ Google Scholar] Patient Neurotoxicity Questionnaire results: significantly lower grades of peripheral neuropathy in the intervention side ( p< .0001) Reduced incidence of ≥ grade 2 peripheral neuropathy in the intervention group (5.0%–9.1%) vs. the control group (22.5%–35.8%); p< .05 at the fourth cycle and p< .01 after the fifth cycleNo statistically significant preservation of hand or foot cold sense, vibration perception, electrophysiological measurements

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National Cancer Institute’s Common Toxicity Criteria, version 2.0, translated into Danish, including sensory neuropathy symptoms Tofthagen C., Overcash J., & Kip K. (2012). Falls in persons with chemotherapy-induced peripheral neuropathy. Supportive Care in Cancer, 20( 3), 583–589. 10.1007/s00520-011-1127-7 [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar]Evaluation before the start of each cycle and 3 weeks after the last chemotherapy in the regional cooling group. Retrospective data from historical cohort provided data from comparable time points Pereira S., Fontes F., Sonin T., Dias T., Fragoso M., Castro-Lopes J. M., & Lunet N. (2016). Chemotherapy-induced peripheral neuropathy after neoadjuvant or adjuvant treatment of breast cancer: A prospective cohort study. Supportive Care in Cancer, 24( 4), 1571–1581. 10.1007/s00520-015-2935-y [ PubMed] [ CrossRef] [ Google Scholar]