The results showed that DNLA significantly attenuated Aβ 25-35-induced spatial learning and memory impairments in mice.

However, many studies do not investigate more than their cytotoxicity against cancer cell lines in vitro, concluding that it suggests their potential for the development of an anticancer drug ( Table 1). Aging is a normal physiological process, which represents the accumulation of changes in human organisms. org), Dendrobium is the second largest orchid genus after Bulbophyllum, widely distributed throughout Asia, Europe and Australia. Dendrobium species have been used for a thousand years as first-rate herbs and a prized folk medicine in India and China [ 1]. huoshanense polysaccharide molecular weight decrease, using pectinase hydrolysis, improved its inhibitory action on nonenzymatic glycation of proteins.

The inhibition of AQP-5 was directly assessed by the addition of human TNF-α on A253 human salivary cell line. Evidently, it is necessary to use the same animal model, administered with extracts from the same extraction procedure at the same dosages for the same period to correctly evaluate the capability of different Dendrobium polysaccharides to decrease blood sugar levels. DCP-H at the concentrations of 25 and 50 μg/mL provided slightly higher stimulation rate as compared to DCP-E, but there was no significant difference between them (p>0.

Treatment of cells with deacetylated stem mucilage was found to maintain cell proliferation, but fail to induce cytokine production. Recently, phenanthrene and bibenzyl derivatives were isolated from Dendrobium nobile, together with two new spirodiketones, namely (-)- and (+)-denobilone A. The majority of reported studies deal with in vitro evaluations of potential anticancer effects of crude Dendrobium extracts or isolated compounds. Indeed, LPS, an inflammation inducer, has been reported to influence Aβ deposition, and LPS injection to the mouse brain ventricle caused memory deficiency and Aβ accumulation.Apoptosis induced by cell detachment was increased in TDB-treated cells and the formation of tumor in anchorage-independent growth was found to be reduced in response to the compound. Moreover, Western immunoblotting revealed that Dendronan ® was able to up-regulate the expression of iNOS protein. Affordable Value: Clear Breath Dendrobium Herbal Drops offer great value for money, making it accessible to everyone. D. officinale also reduced the level of Activin A, Agrin, IL-1α, intracellular adhesion molecule-1, and tissue inhibitor of matrix metalloproteinase-1 and up-regulated the level of IL-10. All the polysaccharide-treatment groups except DNP4-2 exhibited a lower value of spleen index, which indicates that there was no significant increasing effect of the three polysaccharides on the spleen index in the mice.