Fexofenadine at concentrations 32 times greater than the therapeutic concentration in man had no effect on the delayed rectifier K+ channel cloned from human heart.

Human histamine wheal and flare studies following single and twice daily doses of fexofenadine hydrochloride demonstrate that the medicinal products exhibits an antihistaminic effect beginning within one hour, achieving maximum at 6 hours and lasting 24 hours. There is no evidence of tolerance to these effects after 28 days of dosing. A positive dose-response relationship between doses of 10mg to 130mg taken orally was found to exist. In this model of antihistaminic activity, it was found that doses of at least 130mg were required to achieve a consistent effect that was maintained over a 24 hour period. Maximum inhibition in skin wheal and flare areas was greater than 80%. Clinical studies conducted in seasonal allergic rhinitis have shown that a dose of 120mg is sufficient for 24 hour efficacy.In adults, the following undesirable effects have been reported in postmarketing surveillance. The frequency with which they occur is not known (can not be estimated from available data) Weeks of blazing sunshine have been amazing for fans of barbecues, summer days out and festival goers - but not so great for hay fever sufferers. Fexofenadine is not usually recommended if you're pregnant as there is not a lot of information about its use in pregnancy. Fexofenadine hydrochloride is a non-sedating H1 antihistamine. Fexofenadine is a pharmacologically active metabolite of terfenadine. It is recommended that you leave about 2 hours between the time that you take TREATHAY and your indigestion remedy.

There are no data on the content of human milk after administering fexofenadine hydrochloride. However, when terfenadine was administered to nursing mothers fexofenadine was found to cross into human breast milk. Therefore TREATHAY 120 mg tablets is not recommended for mothers breast-feeding their babies. Breast-feeding women should only use TREATHAY 120 mg tablets if advised to do so by a doctor. Fexofenadine is known as a non-drowsy antihistamine. It's less likely to make you feel sleepy than some other antihistamines. Try to take fexofenadine tablets at about the same time every day. Choose a time that is easy to remember. There are no data on the content of human milk after administering fexofenadine hydrochloride. However, when terfenadine was administered to nursing mothers fexofenadine was found to cross into human breast milk. Therefore TREATHAY 120 mg tablets is not recommended for mothers breast-feeding their babies. Breast-feeding women should only use TREATHAY 120 mg tablets if advised to do so by a doctor. Adults and adolescents aged 12 years and over: The recommended dose is one tablet (120 mg) daily. Take your tablet with water before a meal.

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Hayfever sufferers say the tablets are so good, they completely ended their hay fever symptoms. They described the tablets - which are stronger than traditional tablets like Cetirizine Hydrochloride and Loratadine - as making them feel like they don't even have hay fever at all any more.