CAP RAST (Delbourg et al. 1996) [ 42] (Grob et al. 2002) [ 600] (Asero et al. 2003) [ 582] (Sánchez-Monge et al 1999) [ 493] Banana allergy in patients with immediate-type hypersensitivity to natural rubber latex: Characterization of cross-reacting antibodies and allergens. Asero et al. (2003) [ 582] studied 71 patients allergic to fruits and vegetables but not sensitized to lipid transfer protein or natural rubber latex Patients suspected of being allergic to banana, should completely avoid the ingestion of both fresh bananas and of any banana-containing food, until evaluated. Once diagnose of true banana IgE-mediated allergy is confirmed, patient should follow a lifelong banana-free diet. They should also take care of possible unadvertised exposures, since – unfortunately - this food has not been included in the list of potential allergenic ingredients to be labelled, of the new EU labelling directive (2003/89/EC). Due to cross-reactivity, patients considered to be at high risk of banana allergy, as for example subjects allergic to latex, avocado, chestnut, kiwi, melon, or to certain pollens, should be carefully asked about possible previous adverse reactions on banana ingestion. Unless consumption of banana with perfect tolerance is reported by the patient, a banana-free diet should be recommended, until proper diagnosis - on the basis of objective procedures to evaluate clinical reactivity - is made.

out of 4 patients were IgE-CAP positive (> or = class 2) and two were banana-profilin EAST positive (Grob et al. 2002) [ 600]

References (3)

Interestingly, the content of these allergic proteins in fruits can be increased by certain chemical or physical factors. For example, some chemical products used for ripening bananas, clearly induce allergens, therefore rising fruit allergenicity. These proteins seem to be inactivated by heating, which could explain why some plant foods containing these allergens, but only consumed after cooking, are not associated with this syndrome.

In 2011, the Crusha brand was extended to a range of desserts, including Puddings and Jelly. [10] The Milkshake Mix was rebranded as Crusha Mixa, and the Vanilla flavour returned as a limited Edition flavour, now as Vanilla Ice Cream. [11] Banana Crusha was discontinued in shops, but remained a bulk product for cash and carry stores. patients with anaphylaxis; 3 with local sensitivity and 1 with severe abdominal cramping and nausea. (Beezhold et al. 1996) [ 281] Banana is the crescent-shaped edible fruit of any of several species of the musaceous genus Musa, which are tropical and subtropical herbaceous tree-like plants. Meanwhile, Plantain specifically refers to the fruit of Musa paradisiaca, a large tropical musaceous plant, eaten as a staple food in many tropical regions. World banana production is about 65 million tonnes per year, concentrated in Africa, Asia, the Caribbean and Latin America, due to climatic conditions. In Europe, estimated yearly consumption varies among countries, from 5 to 10 kg/capita in the Mediterranean area and the Netherlands, to more than 15 kg/capita in Sweden. Detection of clinical markers of sensitization to profilin in patients allergic to plant-derived foods. IgE cross-reactivity was demonstrated by RAST-inhibition between latex, avocado, chestnut and banana (Blanco et al. 1994) [ 288]

References (6)

Reindl et al. (2002) [ 601] observed that IgE binding to the recombinant profilins was observed in 7/16 sera from subjects with suspected banana allergy (44%) On 5 March 2014, Crusha rebranded fully, scrapping "Errol's Crew" and giving Errol a younger appearance, with kittens doing stunts to make Crusha. [12] The flavour selection rebranded to just raspberry, strawberry and chocolate, with a new No Added Sugar version of the chocolate flavour.

Two bands of 32 and 34 kDa were the major components recognised by sera (Sanchez Monge et al. 1999) [ 493]patients with asthma; 2 with rhinitis; 2 with eczema; 3 with urticaria; 2 with angioedema and 2 with OAS (Makinen-Kiljunen 1994) [ 405] patients with anaphylaxis, 6 cases with angioedema/urticaria, 2 cases with vomits, one case with bronchial asthma, and another case with rhinoconjuntivitis (Blanco et al. 1994) [ 287]. Allergen purification: The recombinant banana profilin was purified by affinity chromatography using poly-(L)-proline as the solid phase and expressed in E. coli. Inhibition experiments indicated similar IgE reactivity of natural and recombinant allergen (Reindl et al. 2002) [ 601] Amino terminal sequencing revealed that both the 32- and 33-kDa proteins (16 residues analyzed) had 80% identity to the N-terminus of hevein (Mikkola et al. 1998) [ 418] Banana furits were peeled, freeze-dried, ground and defatted with cold acetone. The residue was extracted with PBS buffer, centrifuged and dialysed against water. The protein preparation was fractionated by affinity-chromatography on a regenerated chitin column equilibrated with 20 mM Tris-HCl. Elution was performed with 20 mM sodium acetate pH 5.5 followed by 20 mM acetic acid pH 3.2 to elute the retained proteins. The later eluate was fractionated by cation exchange chromatography on a Mono S HR 5/5 column equilibrated with 10 mM sodium acetate. Elution was performed with a salt linear gradient of 0-50% of 0.5 M NaCl (Sanchez-Monge et al. 1999) [ 493]

The presence of cross-reacting allergens in natural rubber latex and banana has been confirmed by immunoblot inhibition (Alenius et al. 1996) [ 5], (Lavaud et al. 1995) [ 102], (Beezhold et al. 1996) [ 281] Cinquetti et al. (1995) [ 304] reported a 3-year-old boy who developed an anaphylactic reaction following banana ingestion and who presented an associated immediate hypersensitivity to latex. With respect to banana-pollen allergy, several patterns of associated allergies have been described. Examples for that are the following clusters: ragweed pollen allergy with banana and melon allergies; multiple pollen allergies with banana, melon, watermelon, citrus fruits and tomato allergies; and Platanus tree pollen allergy with banana, hazelnut, peanut and celery allergies. A group of allergens very common in the plant kingdom seem to be responsible for at least part of these cross-reactions, but other allergens may also be involved.

FREE diet profile

The banana RAST was positive in 12 out of 14 latex-allergic patients studied (Alenius et al. 1996) [ 5]