SHOW THE CELLULAR FACTORY WEAKENING/DYING WITH LESS NAD+. ZOOM OUT TO THE WHOLE BODY, THE ACTIVITY IS DIMMING/GOING DARK. If you’re taking multiple FutureYou Cambridge supplements and have questions about quantities or combinations, just call us on freephone 0800 808 5740. Our award-winning team will be happy to discuss your individual requirements.

On the one hand, a 2014 study of NR on mice showed that supplementation with NR helped protect the mice against liver cancer. 10 And on the other, continuing research demonstrated successful tumor growth inhibition by reducing NAD. 11 Further NAD studies in human subjects with known cancers can help researchers determine how an increase in NAD can affect tumor size and spread. This reaction and the presence of even small amounts of toluene are pretty discouraging in a supplement, particularly when other products, such as Tru Niagen, are available. Small quantities of toluene should not be permissible in a product intended to be taken daily in perpetuity. A: Based on some of the early pharmacokinetics studies of NAD+, it probably does not matter what time of day you take your NAD+. That’s because your NAD+ levels stay elevated for quite a long time after a single dose of NAD+. A paper published in the journal PLoS ONE 2017 described how one daily dose of the NAD+ supplement nicotinamide riboside was able to sustain consistently high blood NAD+ levels (even though the elimination half-life of NAD+ itself was rather short) ( 4 ).

Reviews

Longevity is one of the most exciting use-cases for NAD+, and for this purpose TRU Niagen is definitely the way to go. The high-dosage nicotinamide riboside formulation has no extra ingredients to worry about, and is a great choice for augmenting NAD+ levels in your cells. NAD3 Fountain of Youth by HPN Nutraceuticals takes a multi-ingredient approach, combining niacin and copper in the ionic compound copper nicotinic acid. A 2014 study found that NR supplementation protected mice against certain types of liver cancer. 10 NAD allows other beneficial enzymes to work more effectively within the body, such as: 12 If you want to combine the anti-aging effects of NAD+ and resveratrol, Thorne ResveraCel is a great option to consider. With a solid dose of resveratrol, plus nicotinamide riboside and quercetin, it’s a robust all-around anti-aging supplement that doesn’t keep its eye off its main objective, which is boosting cellular function via NAD+. Thorne ResveraCel provides nicotinamide riboside for NAD+ alongside the powerful antioxidants quercetin, resveratrol, and betaine. This potent combo is great for older adults looking to fight inflammation and oxidative damage, and it doesn’t skimp on the NAD+ dosage even though it has other active ingredients.

PARPs – or poly (ADP-ribose) polymerases – which scientists believe play a role in longevity and healthy aging by reducing the damage to DNAResearch into Tru Niagen and its primary ingredient — nicotinamide riboside (NR) — is ongoing. Still, the research that exists is extremely promising. It shows time and again an increase in nicotinamide adenine dinucleotide (NAD) among a majority of participants that far exceeds numbers in the placebo group. Eight weeks of NR supplementation at the Tru Niagen dose can boost NAD by over 50%. Multiple studies show that when participants take a supplement containing a large enough quantity of NR, their bodies then produce an increased amount of NAD. 18 Tru Niagen's 300mg dose should be enough for most people to see an increase in NAD, but with some studies utilizing 1,000mg doses, there is evidence that 300mg might not be enough for everyone. Studies of humans taking even 1,000-2,000 mg per day of NR (significantly higher than the recommended Tru Niagen dosage) showed no significant harmful effects, though some people taking this higher dose experienced mild side effects such as:

Zhu, Y., Liu, J., Park, J., Rai, P., & Zhai, R. G. (2019). Subcellular compartmentalization of NAD+ and its role in cancer: A sereNADe of metabolic melodies. Pharmacology & Therapeutics, 200, 27.

Directions

If you want to boost your energy production, improve your resistance to the negative effects of obesity, and possibly even sustain better cognitive function into old age, an NAD+ supplement might be able to help. Nicotinamide riboside (or NR) is just a different form of vitamin B3 than niacin. You could find small amounts of NR naturally in products like milk. NR is also known as Niagen, a name patented by the company in focus here: Tru Niagen. But NR isn't found in large amounts naturally. There’s an all-important molecule called NAD+ that’s vital to cellular function. It’s depleted by stressors, too, and also declines naturally as you age. The key active ingredient in Tru Niagen embodies over 50 years of science, and is clinically proven to boost your NAD+ levels. As scientists have conducted more and more studies, they've discovered numerous, very intriguing things about NAD, including the following: