Paula’s Choice Hyaluronic Acid Booster With Ceramides is free of potential irritants like fragrance, parabens, and drying alcohols. We didn’t experience any irritation from using this serum, and we didn’t expect to because it contains soothing ingredients like vitamin B5 and ceramides. Gualdi G, Monari P, Cammalleri D, Pelizzari L, Calzavara-Pinton P. Hyaluronic Acid-based Products are Strictly Contraindicated in Scleroderma-related Skin Ulcers. Wounds. 2019;31(3):81-84. View abstract.

I very much like Skinceuticals’ products and frequently recommend them to my patients,” Dr. Yadav says, adding that it’s bursting with hydrators. A 1.3% concentration of hyaluronic acid is perfect for boosting water content in the skin, while 10% proxylane assists in helping skin retain its moisture for plumper skin. It’s ideal for mature, aging skin, notes Dr. Robinson. Might seem obvious, but it’s actually one of the biggest mistakes people with dry skin make with hyaluronic acid: thinking the only thing they need to use is a serum. Instead, think of hyaluronic acid as a team player that works best when used with a cream. Dr. Talakoub says even though hyaluronic acid holds water in the skin, a normal moisturizer that’s made for people with very dry skin has an emollient to lubricate the skin and an occlusive to hold the oils in the skin. Is sodium hyaluronate the same thing as hyaluronic acid? Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. View abstract.Pellegatta G, Mangiavillano B, Semeraro R, et al. The effect of hyaluronic acid and chondroitin sulphate-based medical device combined with acid suppression in the treatment of atypical symptoms in gastroesophageal reflux disease. J Clin Med 2022;11(7):1890. View abstract.

Wei M, Zou Y, Duan F, et al. Efficacy of Long-term Use of 0.3% Sodium Hyaluronate Eye Drops for Traumatic Corneal Abrasion: A Randomized Controlled, Pilot Trial. Cornea 2021;40(10):1248-1252. View abstract.

Mikosinski J, Di Landro A, Luczak-Szymerska K, et al. Efficacy and Safety of a Hyaluronic Acid-Containing Gauze Pad in the Treatment of Chronic Venous or Mixed-Origin Leg Ulcers: A Prospective, Multicenter, Randomized Controlled Trial. Wounds 2021;33(6):147-157. View abstract. U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection-dermal-fillers-fda-safety-communication. Accessed June 28, 2022. Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J Cosmet Dermatol 2021;20(11):3563-3572. View abstract. Even active ingredients that don’t always mix well with others, such as vitamin C and retinol, play nicely with hyaluronic acid. You can use them in the same routine, and hyaluronic acid can even counterbalance any sensitivity or dryness caused by certain active ingredients. The Mad Hippie serum contains quite a few antioxidants along with hyaluronic acid to combine brightening and hydrating benefits.

We spent over 432 hours testing hyaluronic acid serums, and in the end Isdinceutics Hyaluronic Concentrate was the clear winner. The serum left our skin feeling and looking glowy and even reduced the appearance and frequency of acne breakouts. We’ll keep our list updated as we test new products, so watch this space. Soderberg O, Hellstrom S. Consequences of using hyaluronan-coated tympanostomy tubes. Acta Otolaryngol Suppl 1987;442:50-3. View abstract.

Level up your skincare game with the best hyaluronic acid serums for glowing, hydrated skin

Hyaluronic acid is also the go-to ingredient used in fillers (like lip injections ), says dermatologist Lily Talakoub, MD. It works similarly when injected as it does when applied topically, binding to water in your body and making the skin plump up. The hyaluronic acid used in face fillers is cross-linked, meaning it comes in a gel form that holds it shape to help create volume and structure in the skin, adds Dr. Mansouri. Rolando M, Valente C. Establishing the tolerability and performance of tamarind seed polysaccharide (TSP) in treating dry eye syndrome: results of a clinical study. BMC Ophthalmol 2007;7:5. View abstract. Each 5ml sachet contains 17mg of pure fermentation-based mid-molecular weight Hyaluronic Acid and 12mg (15% RDI) Vitamin C to naturally top up body’s own supply. Since Hyaluronic Acid is a natural substance, it has no known side effect and can be easily incorporated into any lifestyle and daily routine. PureHA provides a well-balanced daily dose of active ingredients to ensure efficient absorption while avoiding empty overconsumption, when the supplement passes through the body without having any effect.

Ibraheem W, Jedaiba WH, Alnami AM, et al. Efficacy of hyaluronic acid gel and spray in healing of extraction wound: a randomized controlled study. Eur Rev Med Pharmacol Sci 2022;26(10):3444-9. View abstract. Other Ingredients: Hyaluronic acid pairs well with common active ingredients and even other products like makeup and sunscreen. During our testing, many hyaluronic acid serums performed nicely as pre-makeup prep, and we didn’t have any issues with pilling or other reactions. You can pair this humectant with pretty much anything, and Dr. Robinson describes it as being “universally beneficial.” Here are some active ingredients you can use with hyaluronic acid, as recommended by dermatologists:Dougados M. Sodium hyaluronate therapy in osteoarthritis: arguments for a potential beneficial structural effect. Semin Arthritis Rheum 2000;30(2 Suppl 1):19-25. View abstract.