The success in caries prevention is based in particular on the wide availability of fluoride in toothpastes [ 9, 10]. Patients at risk of caries, such as the elderly or children of primary dentition age, can be particularly effectively protected from caries by increased fluoride administration—for example, in the form of fluoride gels or varnishes [ 2, 3]. If the recommended dosage is observed, there are no concerns about the use of fluorides even for young children [ 11]. Taking into account the usual recommendations for use in dentistry, there is no toxicological risk for fluorides in toothpastes [ 12]. There may be differences in the mechanism of action related to the size of the HAP particles [ 24]. Clinical efficacy has been found to depend on the specific geometry, pore size, and degradation rate of the HAP, with a smaller particle size being beneficial [ 25].

Majumdar, Ramanuj (2004). Product Management in India. PHI Learning Pvt. Ltd. p.76. ISBN 978-8120312524. Jāsön [23] offers toothpaste among a variety of other personal care products. Jāsön is a brand of Hain Celestial. [24]

The surfaces treated with Elmex showed the lowest percentage of demineralization (mean 5.01 ± 0.98%) ( p< 0.01). Thus, Elmex remineralized more effectively compared to Ajona (8.89 ± 1.41%) and Karex (9.85 ± 1.63%) ( p< 0.01). Furthermore, Elmex showed the lowest percentage of demineralized enamel after new demineralization (median 6.29%), followed by Ajona (11.92%) and Karex (13.46%) ( p< 0.001). Conclusion

Often, a normal amount of toothpaste does not fit on the small head of electric toothbrushes. With Ajona you do not have the problem, as a lens-sized amount is enough to achieve optimal dental care. Marinho VC, Worthington HV, Walsh T, Clarkson JE. Fluoride varnishes for preventing dental caries in children and adolescents. Cochrane Database Syst Rev. 2013:CD002279. https://doi.org/10.1002/14651858.CD002279.pub2 While every care has been taken to ensure product information is correct, food products are constantly being reformulated, so ingredients and allergens may change. Ganss C, Klimek J, Brune V, Schürmann A. Effects of two fluoridation measures on erosion progression in human enamel and dentine in situ. Caries Res. 2004;38(6):561–6. https://doi.org/10.1159/000080587.Ganss C, Hellwig E, Klimek J. Hydroxylapatit in Zahnpasten: Wirkt es oder wirkt es nicht? Zahnärzt Mitt. 2018;108(22):32–44. Close-Up: marketed by Unilever, [10] it was launched in 1967 and was the first gel toothpaste in the world. [11] Ultra Brite: [41] an American toothpaste and tooth-whitener marketed by Colgate-Palmolive in the United States. Helmerhorst EJ, Oppenheim FG. Saliva: a dynamic proteome. J Dent Res. 2007;86(8):680–93. https://doi.org/10.1177/154405910708600802.

Marinho VC, Worthington HV, Walsh T, Chong LY. Fluoride gels for preventing dental caries in children and adolescents. Cochrane Database Syst Rev. 2015:CD002280. https://doi.org/10.1002/14651858.CD002280.pub2 Kalodont: discontinued in 1981, [25] it was originally produced by F. A. Sarg’s Sohn & Co. from Vienna and first sold in Austria-Hungary in 1887. It later became widely distributed, in 34 other countries, and obtained a near-monopoly status that caused the word "kalodont" to become synonymous with the word for "tooth paste" in South Slavic languages. It was also available in Russia in 1927. [26] Aqua, Calcium Carbonate, Glycerin, Sodium Bicarbonate, Sodium Lauryl Sulfate, Urea, Diammonium Phosphate, Menthol, Eucalyptol, Anethole, Bisabolol, Pelargonium Graveolens Flower Oil, Citronellol, Eugenol, Geraniol, Linalool, Mentha Viridis Leaf Oil, Thymol, Aroma, Calcium Citrate, Sodium Saccharin, Alginic Acid. Ajona does not use any dyes or preservatives. Wiegand A, Attin T. Influence of fluoride on the prevention of erosive lesions - a review. Oral Health Prev Dent. 2003;1(4):245–53.Balsara to revamp toothpaste portfolio". The Hindu Business Line. August 6, 2002 . Retrieved March 13, 2012. Garberoglio R, Cozzani G. In vivo effect of oral environment on etched enamel: a scanning electron microscopic study. J Dent Res. 1979;58(9):1859–65. https://doi.org/10.1177/00220345790580090301. Zubne paste– kozmetika i higijena". Poslovni dnevnik (in Croatian). January 20, 2011 . Retrieved September 4, 2011. Weintraub JA, Ramos-Gomez F, Jue B, Shain S, Hoover CI, Featherstone JD, Gansky SA. Fluoride varnish efficacy in preventing early childhood caries. J Dent Res. 2006;85(2):172–6. https://doi.org/10.1177/154405910608500211.

For the present in vitro study, 19 intact human wisdom teeth were used, which were surgically removed before tooth eruption. Surgical removal of all teeth was performed at the Department of Oral and Maxillofacial Surgery at Münster University Hospital (Germany). All patients were of legal age, were fully informed about the planned study, and gave written informed consent to participate. All human specimens were handled strictly according to the “Declaration of Helsinki” (Local ethics protocol code 2021‐608‐f‐N). An in vitro study showed that nano-HAP enabled the remineralization of demineralized enamel, while no difference was observed between pure water and micro-HAP [ 26]. The Karex toothpaste investigated in the present study contains 10% micro-HAP [ 12, 15]. It can be assumed that the micro-HAP particles are less effective in penetrating the lesion body of the demineralized enamel. This would explain the lowest measured remineralization potential in this study, which was even lower than in the control group in which a fluoride- and HAP-free toothpaste was used. Kodaka T, Kobori M, Hirayama A, Abe M. Abrasion of human enamel by brushing with a commercial dentifrice containing hydroxyapatite crystals in vitro. J Electron Microsc (Tokyo). 1999;48(2):167–72. https://doi.org/10.1093/oxfordjournals.jmicro.a023663.Formula: an oral care brand from Indonesia since 1984, it was owned by PT Ultra Prima Abadi company and marketed through OT consumer goods brand. [20] Macleans: a brand of toothpaste by GlaxoSmithKline, introduced in UK in the 1930s by the Maclean's Company which was taken over by the Beecham Group and eventually by SKB. Sold and made in many countries and available in the US until the early 1980s, now marketed in Australia and New Zealand. [ citation needed] Colgate: marketed by Colgate-Palmolive, it is the first toothpaste in a collapsible tube, introduced in 1896, after having been sold in glass jars since 1873. [12]