Macrorheological Measurements Taking into Account Interactions with Simulated Gastric Fluid and Gastric Mucins AjlaSA, et al. (2010). Efficacy of papain-based wound cleanser in promoting woundregeneration [Abstract]. Questionsand answers about FDA’s enforcement action regarding unapproved topical drugproducts containing papain. (2015). Papaya fruit is naturally high in papain, a potent proteolytic enzyme. Proteolytic enzymes biologically support the breakdown of proteins. Papaya has a long traditional use in both Traditional Chinese Medicine (TCM) and Ayurvedic Medicine, and historically it has been used to assist in the digestion of proteins, and to more thoroughly “breakdown” food particles, which may in turn speed up transit time. Privola se daje jasnom potvrdnom radnjom i to pisanom izjavom – putem obične pošte, neposredno u prostorijama društva voditelja obrade ili na prodajnim mjestima Voditelja obrade u okviru sajma ili nekog drugog događanja, elektronske pošte (na poslovnu adresu društva, na e-poštu Voditelja obrade) odnosno popunjavanjem kontakt forme na našoj internetskoj stranici.

Caricol® is a Dietary Supplement suitable for the elderly, babies and children, as well as during pregnancy and breastfeeding. https://www.fda.gov/drugs/guidancecomplianceregulatoryinformation/enforcementactivitiesbyfda/selectedenforcementactionsonunapproveddrugs/ucm119646.htm APĂ; PIURE DIN FRUCTE DE PAPAYA* (CARICA PAPAYA) - 39,4 %; FAINA DE OVAZ* (AVENA SATIVA) - 6,25 %; SUC CONCENTRAT DIN FRUCTE DE MAR (MALUS DOMESTICA).To round off the flavour, organic fruit juice concentrate from apple is used, which is responsible for the fruity sweetness of Caricol. Research also suggests that papain may be used as a natural remedy for skin ulcers, wounds, and other skin conditions. Nama je zaštita Vaše privatnosti vrlo važna, stoga nikad nećemo dijeliti Vaše osobne podatke s trećim stranama u svrhu koja nije opisana ovom Politikom. Čuvanje i zaštita osobnih podataka Voditelj obrade će o povredi osobnih podataka izvijestiti nadzorno tijelo bez nepotrebnog odgađanja i to, ako je izvedivo, najkasnije 72 sata nakon saznanja o toj povredi osobnih podataka, osim ako Voditelj obrade može dokazati, u skladu s načelom odgovornosti, da povreda osobnih podataka vjerojatno neće prouzročiti rizik za prava i slobode pojedinaca. Ako se takvo obavješćivanje ne može postići u roku od 72 sata, obavijest bi trebala biti popraćena razlozima kašnjenja, a informacije se mogu pružiti u fazama bez nepotrebnog daljnjeg odgađanja. Čuvanje osobnih podataka Oral administration of aqueous and methanolic extracts of whole, unripe C. papaya fruit of up to 5,000 mg/kg in mice did not produce lethality or signs of acute toxicity after 24 hours. Ezike 2009

conține fructe de papaya coapte preparate bio, ovăz preparat organic și concentrat din suc de mere; Kako bismo osigurali normalnu funkcionalnost naše internetske stranice, koristimo isključivo neophodne kolačiće koji su potrebni kako bi se osigurao normalan i efikasan rad internetske stranice. Ne koristimo kolačiće marketing i analitiku Kolačići su male datoteke koje se privremeno pohranjuju na Vašem računalu. Kolačićima koji se čuvaju na Vašem računalu možemo pristupiti onda kada Vi posjetite našu internetsku stranicu. Želite li obrisati kolačiće koji su na Vašem računalu, pogledajte upute u svojem internetskom pregledniku klikom na „Pomoć“. Forma za kontakt na internetskoj straniciFrom recently performed clinical studies it is obvious that Caricol ®-Gastro shows adhesive properties to the gastric mucosa due to its pain-reliving effects in the clinical course of chronic gastritis [ 14]. To be able to build up a sound understanding of the mechanisms behind adhesive effects in a cost-effective and time-saving manner, related in vitro mucoadhesive test methods that take into account the physiological conditions of the respective barrier are highly important. Moreover, the establishment of such a tool would also allow to predict performances of other mucoadhesive dosage forms and facilitate rational formulation design. Thus, a combination of different methods, i.e., rheological methods, visualization of the network by SEM, in vitro wettability studies using the sessile drop method, and ex vivo studies conducted with the falling liquid film method were used and adjusted where necessary to investigate the mechanisms of adhesion of the model formulation Caricol ®-Gastro. Quantification of the material that was washed off the gastric mucosa was performed with Franz diffusion cells using methylene blue as staining agent. To examine whether the adhesive effects were mainly due to oat flour, we investigated pure oat preparations at different concentrations. Papaya is contraindicated in patients with known hypersensitivity to any of its components (eg, papain). Papaya may induce severe allergic responses in sensitive people. Pregnancy/Lactation Ispitanik daje svoju privolu jasnom potvrdnom radnjom kojom izražava dobrovoljan, poseban, informiran i nedvosmislen pristanak na obradu osobnih podataka koji se odnose na njega, poput pisane izjave, uključujući elektronsku. Caricol is free from artificial preservatives, colours, flavours, filling agents and MSG. It is stable for 18 months when stored under 25 degrees centigarde Rheological investigations of Caricol ®-Gastro with simulated gastric fluid (SGF) ( a), oat I with SGF ( b), oat II with SGF ( c) at 37 °C.

In an attempt to document papaya's use, a 15-item questionnaire was used to interview 9 nurses in Jamaica who used papaya to treat pressure ulcers. Hewitt 2002 It was discovered that nurses used grated unripe papaya blended into a paste for application twice daily, once daily, or on alternate days to the ulcers. The ulcers were cleaned with normal saline, Eusol, or soap and water Hewitt 2002, Singhal 2001 prior to application and then covered with gauze to keep the papaya in place. Hewitt 2002, Sieggreen 1997 The interviewees reported that the slough was easily removed from the ulcer after the papaya had been applied for about 1 week, at which time granulation tissue was evident. When healing was slow, papaya was used in conjunction with systemic antibiotics or topical Eusol, tetracycline, or mupirocin. Hewitt 2002, Singhal 2001 All participants interviewed were convinced that applying unripe papaya to pressure sores was effective. Hewitt 2002 Pojašnjenje o okolnostima radi kojih Ispitaniku neće uopće ili neće u roku biti dostavljena tražena informacija ili izvršena izmjena osobnih podataka Voditelj obrade – fizička ili pravna osoba, tijelo javne vlasti, agencija ili drugo tijelo koje samo ili zajedno s drugima određuje svrhe i sredstva obrade osobnih podataka; kada su svrhe i sredstva takve obrade utvrđeni pravom Unije ili pravom države članice, voditelj obrade ili posebni kriteriji za njegovo imenovanje mogu se predvidjeti pravom Unije ili pravom države članice. Ispitanik – pojedinac čiji se identitet može utvrditi odnosno osoba koja se može identificirati izravno ili neizravno, osobito uz pomoć identifikatora kao što su ime, identifikacijski broj, podaci o lokaciji, mrežni identifikator ili uz pomoć jednog ili više čimbenika svojstvenih za fizički, fiziološki, genetski, mentalni, ekonomski, kulturni ili socijalni identitet tog pojedinca (korisnik odnosno kupac naših proizvoda). Priprava Caricola poteka po patentiranem proizvodnem procesu, ki za 7-krat izboljša učinek papaje na prebavo in za 4-krat poveča njeno encimsko učinkovitost.obrada je nužna za izvršavanje ugovora u kojem je Ispitanik stranka ili kako bi se poduzele radnje na zahtjev Ispitanika prije sklapanja ugovora Pravo na brisanje: možete nas zatražiti prekid obrade ili čak brisanje osobnih podataka koje posjedujemo. Brisanje osobnih podataka može se tražiti primjerice ako ste povukli svoju privolu za obradu Vaših podataka, kada se Vaši osobni podaci nezakonito obrađuju ili kada Vaš osobni podaci više nisu nužni za svrhe za koje su prikupljeni. Međutim molimo Vas da uvažite da Vaše osobne podatke nećemo moći izbrisati ako su potrebni radi ispunjenja zakonskih obaveza, ugovornih obaveza i drugih pravnih temelja iz Opće uredbe o zaštiti osobnih podataka.

The name Caricol is derived from CAR ica papaya L. which is the botanical name for papaya; and COL, representing the colon, where traditional use has seen its predominant effect.

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Histologic examination of sections of pituitary gonadotrophs (follicle-stimulating hormone and luteinizing hormone cells) in male Wistar rats treated with C. papaya extract 200 mg/kg/day for 1 and 8 weeks revealed pronounced hypertrophy, while those treated with 50 mg/kg showed mild hypertrophy and hyperplasia. The testes of rats treated with C. papaya revealed gradual degeneration of the germ cells, Sertoli cells, and Leydig cells, as well as germinal epithelium. Tubules of epididymis of rats treated with 200 mg/kg of extract appeared empty, indicating the degeneration of sperm cells in the lumina. These results suggest C. papaya extract interfered with the pituitary-gonadal axis to influence male reproductive functions. Udoh 2005 Posebne sestavine, ki izhajajo iz patentiranega postopka priprave papaje, izboljšujejo fermentacijo in nadaljni prenos hrane skozi črevesje. Studies have also been performed to evaluate the toxicological effects of papaya seed extract and whether this effect is reversible even after high concentrations and long-term administration. One such study in mice revealed a dose-dependent suppression of sperm motility coinciding with a decrease in sperm count and viability with high dosages of aqueous C. papaya seed extract. Forty-five days after withdrawal of treatment, complete normalcy was restored. Verma 2006 Another study in mice administered 50 mg/kg/day showed 100% sterility after 60 days, and safety was demonstrated after 360 days based on unaltered health status, organ weight, hematology, and clinical chemistry, and by an increase in body weight. All altered parameters, including percent fertility, were restored to control levels 120 days after treatment withdrawal. Manivannan 2009