If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately. Viagra may protect against heart disease and other cardiovascular events, new data suggests April 3, 2023 CBD can also affect how your liver works, so doctors would need to monitor you regularly. How do I get a prescription? Sativex is a spray you use in your mouth. It contains two chemicals from the cannabis plant called cannabinoids. They’re in an equal mix of tetrahydrocannabinol (THC) and cannabidiol (CBD).

Patients on hormonal contraceptives should be advised to use an additional alternative, non-hormonal/reliable barrier method of birth control during Sativex therapy.

You may also be interested in

In a study designed to identify its abuse potential, Sativex at a dose of 4 sprays taken at one time did not differ significantly from placebo. Higher doses of Sativex of 8 to 16 sprays taken at one time did show abuse potential comparable to equivalent doses of dronabinol, a synthetic THC. In a QTc study a dose of Sativex 4 sprays over 20 minutes twice daily was well-tolerated, but a substantially supratherapeutic dose of 18 sprays over 20 minutes twice daily resulted in significant psychoactivity and cognitive impairment. The NICE guideline on cannabis-based medicinal products recommends that, providing the local NHS health authority ( integrated care system, or ICS) is willing to pay for continued treatment, a 4-week trial of Sativex can be offered to people with moderate to severe MS-related spasticity which has not improved while taking other treatments. At the end of the trial, if their spasticity-related symptoms are reduced by at least 20%, they can continue taking Sativex. CBD and THC can affect how other medicines work. Always discuss possible interactions with a specialist.

Sativex doesn’t work for lots of people. But for those it does work for, their spasticity symptoms get significantly better. When people use Sativex around 7 in 10 of them see their spasticity reduce by at least 20%. And spasticity is reduced even more for some people - by 30% or more for around 4 in every 10 people. In England, the National Institute for Health and Care Excellence (NICE) recommends which drugs you can get on the NHS. In 2019 it decided Sativex could be available to people in England with ‘moderate’ to ‘severe’ spasticity. This is only when other treatments haven’t helped. This medicine should not be used if you are allergic to any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. Sativex has been studied at doses of up to 48 sprays/day in controlled clinical trials of up to 19 weeks duration in more than 1500 patients with MS. In the pivotal trials to assess the efficacy and safety of Sativex for symptom improvement in patients with moderate to severe spasticity due to multiple sclerosis (MS) the primary efficacy measure was a 0 to 10 point Numeric Rating Scale (NRS) on which patients indicated the average level of their spasticity related symptoms over the last 24 hours where 0 is no spasticity and 10 is the worst possible spasticity. These medicines are appropriate for initiation in both primary and secondary care. Prescribing is appropriate within licensed or local recommendations.

What is Salivix Spray used for?

Salivix Spray contains malic acid, which is a recognised sialagogue (the medical term for a substance that promotes the secretion of saliva). To help improve moderate to severe symptoms of multiple sclerosis, such as stiffness and spasms, that are caused by muscle tightening (spasticity). Suitable for patients who have an intact oral cavity, i.e., no bleeding ulcers. Salivix spray can be used in pregnancy and during breastfeeding. Adults (including the elderly) and children over 6 years: apply 2-4 sprays into the oral cavity when needed up to 16 times a day. It was postulated that a clinically useful treatment effect in some patients might be partly masked by data from non-responders in the analyses of mean changes. In analyses comparing NRS scores with patient global impression of change (PGI), a 19% NRS response was estimated to represent a clinically relevant improvement on the PGI and a response of 28% “much improved” on the PGI. In post hoc exploratory combined analyses of the above two studies, a 4-week trial period using a 20% NRS response threshold was predictive of eventual response defined as a 30% reduction.

Sativex oromucosal spray contains two active ingredients, tetrahydrocannabinol (THC) and cannabidiol (CBD), both of which are known as cannabinoids. They are extracted from the leaf and flower of the Cannabis Sativa plant. Acid Reflux Heartburn is a burning feeling in the chest caused by stomach acid travelling up towards the throat (acid reflux). If it keeps happening, it’s called gastro-oesophageal reflux disease (GORD).In some cases, however, it may be prescribed for pain as part of a clinical trial. What about products available to buy? Salivix Spray is a saliva stimulant rather than a saliva substitute. In mild to moderate dry mouth, natural saliva stimulation should be treatment of choice. Sativex may impair the mental and/or physical abilities required for certain potentially hazardous activities such as driving a car or operating machinery. Driving or using machinery when you first start taking Sativex is not recommended until you are established on a stable daily dose. Note: Lozenges and sprays have not been considered for formulary inclusion. The BNF states: ‘There is no convincing evidence that antiseptic lozenges and sprays have a beneficial action and they sometimes irritate and cause sore tongue and sore lips. Some of these preparations also contain local anaesthetics, which relieve pain but may cause sensitisation.’ Applies to saliva substitutes topical: oral gel, oral lozenge, oral paste, oral powder for reconstitution, oral solution, oral spray, oral swab, oral tablet. Gastrointestinal

The medicine should be sprayed under the tongue or onto the inside of your cheek. It is absorbed into the bloodstream through the rich supply of blood vessels in these areas. MHRA DSU Sept 2017 Miconazole (Daktarin): over-the-counter oral gel contraindicated in patients taking warfarin

Product Therapy Areas

The spray can be used either with or without food. However, food can affect how much of the medicine is absorbed, so it is best to try and always use the spray at the same time in relation to food, so you get the same effect each time. As Sativex is placed in the less-restrictive Schedule 4, this means that it can be prescribed legally in the UK with no restrictions on supply, recording, storage or destruction. ​It can only be prescribed by a specialist doctor with experience of treating MS spasticity – consultant neurologists, consultant rehabilitation specialists and consultant pain specialists. Patients who have a history of substance abuse, may be more prone to abuse Sativex as well (see section 5.1).