Representative western blot (A) and quantitative analysis (B) of regulatory proteins in Panc TuI (A) and BxPC3 (B) cells. pACC: Time‐dependent increase of ACC‐1 phosphorylation at Ser79 and of Raptor at Ser792 following incubation of Panc Tul (250μM GP‐2250) and BxPC3 (500μM GP‐2250). pRaptor: Time‐dependent Raptor phosphorylation at Ser 792 in PancTul and BxPc3 cells incubated with 500 and 1000μM GP‐2250. p53: Time‐dependent increase of protein level of p53 in Panc Tul and BxPC3 cells (500μM GP‐2250). Akt and mTor: Time‐dependent decrease of the protein level of Akt and mTor at 1000μM GP‐2250 in Panc TuI and BxPC3 cells. Bcl2: Time‐dependent downregulation of protein level of Bcl2 following incubation of Panc Tul and BxPC3 cells (500μM GP‐2250). ß‐Actin/HSP‐90 used as internal controls. Gutterød E. S., Pulumati S. H., Kaur G., Lazzarini A., Solemsli B. G., Gunnæs A. E., Ahoba-Sam C., Kalyva M. E., Sannes J. A., Svelle S., Skúlason E., Nova A., Olsbye U., J. Am. Chem. Soc., 2020, 142, 17105

Lu G., Li S. Z., Guo Z., Farha O. K., Hauser B. G., Qi X. Y., Wang Y., Wang X., Han S. Y., Liu X. G., DuChene J. S., Zhang H., Zhang Q. C., Chen X. D., Ma J., Loo S. C. J., Wei W. D., Yang Y. H., Hupp J. T., Huo F., Nat. Chem., 2012, 4, 310 The causative link between the cytotoxicity of GP‐2250 and the inhibition of the glycolytic enzymes and the TCA cycle was demonstrated in two rescue experiments. The ability of supplementary OAA and PYR to largely rescue tumour cells from drug‐induced cytotoxicity is evidence that the deficit in glycolytic and TCA cycle‐dependent energy metabolism is the major cause for the cytotoxicity of GP‐2250 (Figure 3A–D). Zhang W. L., Ji W. L., Li L. J., Qin P. S., Khalil I. E., Gu Z. D., Wang P., Li H. F., Fan Y., Ren Z., Shen Y., Zhang W. N., Fu Y., Huo F. W., ACS Appl. Mater. Interfaces, 2020, 12, 52660

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Kemnitz K, Yoshihara K (1991) Entropy-driven dimerization of xanthene dyes in nonpolar solution and temperature-dependent fluorescence decay of dimers. J Phys Chem 95:6095–6104

Choe K., Zheng F. B., Wang H., Yuan Y., Zhao W. S., Xue G. X., Qiu X. Y., Ri M., Shi X. H., Wang Y. L., Li G. D., Tang Z. Y., Angew. Chem. Int. Ed., 2020, 59, 3650 In most countries, patients receiving mechanical ventilation (MV) are treated in intensive care units (ICUs). However, in some countries, including Japan, many patients on MV are not treated in ICUs. There are insufficient epidemiological data on these patients. Here, we sought to describe the epidemiology of patients on MV in Japan by comparing and contrasting patients on MV treated in ICUs and in non-ICU settings. A preliminary comparison of patient outcomes between ICU and non-ICU patients was a secondary objective. Methods Shen H. F., Li H., Yang Z. S., Li C. L., Green Energy Environ., 2022, doi: https://doi.org/10.1016/j.gee.2022.01.013 Nag A, Goswami D (2009) Solvent effect on two-photon absorption and fluorescence of rhodamine dyes. J Photochem Photobiol A Chem 206:188–197Characters were built of line segments specified by display list subroutines. Thus any character set or font could be displayed, although fonts were generally extremely simplified for performance reasons. Sirio CA, Tajimi K, Taenaka N, et al. A cross-cultural comparison of critical care delivery: Japan and the United States. Chest. 2002;121:539–48.