Using tools, like gravimetrics, to tell us whether we managed to get within acceptable limits and to demonstrate appropriate performance during the compounding process. I have observed computation of a weight-based dose of chemotherapy to be 50.2 mL of a drug and seen the pharmacist draw up 50 mL in a 50 mL syringe, and 0.2 mL of the drug in a 1 mL syringe Adaptor: This is the area where you screw on a needle (if you were giving an intramuscular injection etc.) or onto the IV hub of the patient’s IV to give a medication. The amount of medication in a source container of an injection is defined by the USP monograph for that injection. For example, according to the monograph for Cefazolin Sodium for Injection, a container is considered accurately filled if it contains between -10% and +15% of its labeled potency. Based on looking at over 250 monographs of liquid injections, most are within ±10% (though there are some significant outliers. Again, this doesn’t mean that all instances of any product are at these limits; it does mean that any instance of a product could be at these limits and be considered to be accurately filled. Tuberculin Syringe Small-volume syringe, with a 1-mL capacity, used for intradermal skin tests and small-volume injections in frail at-risk populations.

Tip: If you hear someone say give “10 cc” of this medication, cc is the same as mL. Therefore, 10 mL equals 10 cc. Reading a 10 mL Syringe The reality from ISO7886-1, however, is that delivering 9.6 mL from a 10 mL syringe has a ±4% precision, which means that we only know for certain that we delivered somewhere between 9.22 and 9.98 mL of diluent. Presuming the expansion from 9.6 to 10 mL is roughly linear within this narrow range, that means that our resulting volume is somewhere between 9.6 and 10.4 mL, so our concentration is somewhere between 86.5 mg/mL (900 mg/10.4 mL) and 119.8 mg/mL (1,150 mg/9.6 mL).Low dead space can be achieved in detachable syringes and needles through designing either the syringe or needle components to have low dead space. The difference between high and low dead space syringes is determined by the average quantity of fluid that cannot be expelled from the device. Although no set standard for the designation of low dead space syringes and needles exists, it is the convention to designate any needle or syringe design that deviates from the standard needle and syringe design as low dead space if this new design yields a lower dead space. [1] Intramuscular (IM) Into the muscle. The muscle is able to accept more irritating substances than other injectable routes. Carroll, Jennifer J. (15 June 2019). Narkomania: Drugs, HIV, and Citizenship in Ukraine. Cornell University Press. p.47. ISBN 978-1-5017-3693-3.

As opposed to low dead space syringes, high dead space syringes are conventional needle and syringe designs. The term "high dead space" refers to the fluid remaining within the needle and between the syringe hub and the plunger. This space can be as high as 84 micro liters in conventional syringes. [2] There’s a reason that children’s’ hospital pharmacies prepare dilutions; they create doses they can actually measure with acceptable accuracy. a b "Archived copy" (PDF). Archived from the original (PDF) on 2015-05-08 . Retrieved 2016-02-08. {{ cite web}}: CS1 maint: archived copy as title ( link)

Reading a 3 mL Syringe

Given all the inherent error in the systems we operate, the best we can do is to operate those systems as best we can. This means: Applying this same analysis to liquid medications (with a variance of ±10%), we are looking at roughly a ±14% variance (removes reconstitution variance). Insulin Syringe Small syringe, with a 0.3- to 1-mL capacity, calibrated for specific insulin mixtures in standardized units. Parenteral Medications Injectable medications. Excludes oral, nasogastric, gastric, topical, and intestinal routes. Syringes below 5 mL are accurate if they can deliver within ±5% when measuring 50% or more of their nominal volume. For a 1 mL syringe, this means that we know, at best that measuring a 1 mL volume in that syringe will deliver somewhere between 0.95 and 1.05 mL.

This section does not cite any sources. Please help improve this section by adding citations to reliable sources. Unsourced material may be challenged and removed. ( February 2021) ( Learn how and when to remove this template message) Below 50% of its nominal volume, the accuracy of the syringe declines with the volume measured until, at 10% of its nominal volume, it delivers ±16% accuracy. So when measuring a volume of 0.1 mL in a 1 mL syringe, the best you can actually know is that you are delivering somewhere between 0.084 and 0.116 mL. At 20% of its nominal volume, such a syringe delivers ±9.5% of its apparent measured volume, so, if we were to set ±10% as our acceptable standard of accuracy, then the lowest volume we can accurately measure with any syringe available to us is 0.2 mL

Reading a 5 mL Syringe

The most accurate syringe in common use has an accuracy of ±4% when its nominal volume is 5 mL or greater when delivering at 50% or more of its nominal volume.