Kusama,S.; Sato,K.; Matsui,Y.; Kimura,N.; Abe,H.; Yoshida,S.; Nishizawa,M. Nat.Commun. 2021, 12, 658. doi:10.1038/s41467-021-20948-4 Wróblewska,K.B.; Milanowski,B.; Kucińska,M.; Plewa,S.; Długaszewska,J.; Muszalska-Kolos,I. Pharmaceuticals 2021, 14, 849. doi:10.3390/ph14090849 Mönkäre,J.; RezaNejadnik,M.; Baccouche,K.; Romeijn,S.; Jiskoot,W.; Bouwstra,J.A. J.ControlledRelease 2015, 218, 53–62. doi:10.1016/j.jconrel.2015.10.002 After 6 weeks my eyes are noticeably brighter, and the dark circles are disappearing which is nice to see and the lines around my eyes have softened. I’m going to continue to use weekly to maintain my results and also to see how they continue to improve over time. Any tips for post-treatment? You can apply the Brightening Eye Serum again and follow with the Icelandic Relief Eye Cream to help de-puff and reduce appearance of dark circles.

The paper noted that skin microneedling was a relatively minimally invasive procedure. The microneedle itself can reach down into the mid-dermis, and bleeding after application of is a common result that initiates the wound healing process. It’s recommended that you use the Pimple Patches at the first sign of a pimple, and the Plumping Patches twice a week to begin with. My experience with microneedling patches Huang,D.; Chen,Y.-S.; Rupenthal,I.D. Adv.DrugDeliveryRev. 2018, 126, 96–112. doi:10.1016/j.addr.2017.09.008 Adenosine for decreasing crow’s feet wrinkles (there was also 140 times less adenosine in the patch!) cruelty free Created with Sketch. no oil Created with Sketch. water Created with Sketch. vegan Created with Sketch. derm Created with Sketch. bunny Created with Sketch.Andrés-Guerrero,V.; Bravo-Osuna,I.; Pastoriza,P.; Molina-Martinez,I.T.; Herrero-Vanrell,R. J.DrugDeliverySci.Technol. 2017, 42, 181–192. doi:10.1016/j.jddst.2017.07.001 drug containing tip after optimization was delivered to the mouse cornea and efficiently reduced progression of keratitis Tan,G.S.; Cheung,N.; Simó,R.; Cheung,G.C.M.; Wong,T.Y. LancetDiabetesEndocrinol. 2017, 5, 143–155. doi:10.1016/s2213-8587(16)30052-3 Herrero-Vanrell,R.; VicariodelaTorre,M.; Andrés-Guerrero,V.; Barbosa-Alfaro,D.; Molina-Martínez,I.T.; Bravo-Osuna,I. J.DrugDeliverySci.Technol. 2013, 23, 75–102. doi:10.1016/s1773-2247(13)50016-5

I absolutely love these! They have been a godsend for my undereyes. I could not be more impressed. These patches are incredibly easy to use and provide noticeable results. I love the colloidal patches for acne. I’ve seen some micro needle patches at Sephora (Dr. Jart and another brand I can’t remember) that are more wallet friendly. I was curious about them so thanks for the info! Reply Mondal,K.; Mandal,N. Role of Bioactive Sphingolipids in Inflammation and Eye Diseases. In The Role of Bioactive Lipids in Cancer, Inflammation and Related Disease; Honn,K.V.; Zeldin,D.C., Eds.; Advances in Experimental Medicine and Biology; Springer International Publishing: Cham, 2019; pp149–167. doi:10.1007/978-3-030-21735-8_14 Hui,A.; Bajgrowicz-Cieslak,M.; Phan,C.-M.; Jones,L. Clin.Ophthalmol. 2017, 11, 1657–1665. doi:10.2147/opth.s141404Sadeqi,A.; Kiaee,G.; Zeng,W.; RezaeiNejad,H.; Sonkusale,S. Sci.Rep. 2022, 12, 1853. doi:10.1038/s41598-022-05912-6

A few studies have found that dissolving microneedle patches worked better than essences with the same ingredients: Shi,H.; Zhou,J.; Wang,Y.; Zhu,Y.; Lin,D.; Lei,L.; Vakal,S.; Wang,J.; Li,X. Small 2022, 18, 2104657. doi:10.1002/smll.202104657 Achouri,D.; Alhanout,K.; Piccerelle,P.; Andrieu,V. DrugDev.Ind.Pharm. 2013, 39, 1599–1617. doi:10.3109/03639045.2012.736515 Suriyaamporn,P.; Opanasopit,P.; Ngawhirunpat,T.; Rangsimawong,W. J.DrugDeliverySci.Technol. 2021, 61, 102319. doi:10.1016/j.jddst.2020.102319 Yadav,V.; Sharma,P.K.; Murty,U.S.; Mohan,N.H.; Thomas,R.; Dwivedy,S.K.; Banerjee,S. Int.J.Pharm. 2021, 605, 120815. doi:10.1016/j.ijpharm.2021.120815In a subsequent work, the authors presented two types of patches for the delivery of triamcinolone acetonide (TA), a model steroidal drug applied in numerous inflammatory conditions to the posterior segment of the eye. A microneedle scleral patch (MSP) and a microneedle corneal patch (MCP) were obtained by micromolding with the use of PVP. The ex vivo experiments performed on porcine eye globe showed that, in comparison to MCP and TA nanosuspension, MSP yielded much greater TA concentrations in the vitreous humor and choroid-retinal complex after 5 min of application. Moreover, the patches were tested with a rabbit eye model. In this case, after 24 h, significantly higher TA accumulation was observed for MSP in comparison to MCP and intravitreal injection [175].

Norman,R.E.; Flanagan,J.G.; Rausch,S.M.K.; Sigal,I.A.; Tertinegg,I.; Eilaghi,A.; Portnoy,S.; Sled,J.G.; Ethier,C.R. Exp.EyeRes. 2010, 90, 277–284. doi:10.1016/j.exer.2009.11.001 Wróblewska,K.B.; Jadach,B.; Muszalska-Kolos,I. Int.J.Pharm. 2021, 607, 121012. doi:10.1016/j.ijpharm.2021.121012 Martanto,W.; Davis,S.P.; Holiday,N.R.; Wang,J.; Gill,H.S.; Prausnitz,M.R. Pharm.Res. 2004, 21, 947–952. doi:10.1023/b:pham.0000029282.44140.2e Rashid,M.A.; Naz,T.; Abbas,M.; Nazir,S.; Younas,N.; Majeed,S.; Qureshi,N.; Akhtar,M.N. ColloidInterfaceSci.Commun. 2019, 28, 41–48. doi:10.1016/j.colcom.2018.11.006 Prausnitz,M.R.; Jiang,N.; Edelhauser,H.F. Method for Drug Delivery to Ocular Tissue Using Microneedle. WO2007131050A3, Feb 14, 2008.However, the treatment can induce microinjuries in the stratum corneum and keratinocytes, which stimulate inflammatory responses from keratinocytes, resulting in stimulation of dermal fibroblast,”​ it added.