Competition for nutrients– within the gut beneficial and pathogenic micro-organisms will be utilising the same types of nutrients. This results in a general competition between bacteria for these nutrients. When a probiotic is administered there is an overall reduction in nutrients available for pathogenic bacteria and consequently this minimises the levels of pathogenic micro-organisms. We recommend using 15ml and 30ml syringes for small to medium dogs and the 60ml syringe for larger dogs. Pro-Kolin Advanced has a 2 year shelf life from the date of manufacture. Once open replace the lid securely and store in a cool dry area. Stored correctly Pro-Kolin Advanced will last until the Best Before End date even if it has been opened.

Safety– the micro-organism chosen must be non-pathogenic and non-toxic. Within the EU all probiotics must be registered for use in an individual animal species. For example, Enterococcus faecium (NCIMB 10415) E1707 is registered for use in dogs. We reccomend using 15ml and 30ml syringes for small to medium dogs but also in a handy 60ml syringe for larger dogs. Pro-Kolin Advance has also had a clinical trial done, with it used on Dogs with acute diarrhoea. It significantly improved speed of recovery from acute diarrhoeas, link to this research paper is below: A natural 'friendly' bacterium, Enterococcus faecium (DSM 10663/ NCIMB 10415) 4b1707, which helps to keep the level of beneficial bacteria high and exclude pathogenic species.

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Available in 15ml, 30ml and 60ml syringes for dogs and 15ml syringes for cats, Pro-Kolin Advanced features new and improved flavourings and specific formulations for cats and dog. Both flavourings contain no proteins or common allergens and can be used in animals with known hypersensitivities – ensuring excellent palatability for both cats and dogs, and ongoing owner compliance. Pro-Kolin Advanced contains beneficial micro-organisms, several prebiotic sources, an optimal level of a dual-source binding agent and soothing fibres to support gastrointestinal function. A natural ‘friendly’ bacterium, Enterococcus faecium (DSM 10663/ NCIMB 10415) 4b1707, which helps to keep the level of beneficial bacteria high and exclude pathogenic species. Protexin Veterinary’s clinical study provides much-needed evidence to help clinicians determine the optimal treatment for dogs with acute diarrhoea.

Lactic acid production– probiotics produce lactic acid which acts to reduce the gut pH, inhibiting the growth of pathogenic bacteria, which prefer a more alkaline environment. A natural ‘friendly’ bacterium, Enterococcus faecium, which helps to keep the level of beneficial bacteria high and exclude pathogenic species. Kaolin and Montmorillonite- A dual benefit natural binding agent which helps to firm up the faeces. Preplex prebiotics - A prebiotic, consisting of fructo-oligosaccharide (FOS) and acacia (Gum arabic), which helps to feed and stimulate the growth of beneficial bacteria.Improvement in digestion– probiotics have been shown to increase the efficiency of digestion and therefore provide an improvement in digestion.