Queries for heat-not-burn in Japan occur more frequently than queries for e-cigarettes in the United States, with the Japanese heat-not-burn queries first eclipsing e-cigarette queries in April 2016. [138] Further, the change in average monthly queries for heat-not-burn in Japan between 2015 and 2017 was 399 (95% CI: 184–1,490) times larger than the change in average monthly queries for e-cigarettes in the United States over the same time period, increasing by 2,956% (95% CI: 1,729–7,304) compared to only 7% (95% CI: 3–13), which indicate that interest in heat-not-burn may outpace interest in e-cigarettes in the future. [138]

Significant reduction in white blood cell count, an inflammatory mark The availability of flavours in HTP products may appeal to non-smokers, [23] and evidence suggests that individuals who have never used tobacco products, especially children and adolescents, could be susceptible to new products that could lead to the use of traditional cigarettes. [3] In 2017, the Committee on Toxicity noted that "[c]ommittees were particularly concerned for young people, who do not smoke, starting to use these products, due to the potential for longer exposure over the remainder of their lives compared to adults and to possible differences in sensitivity." [56] a b Drope, Jeffrey; Cahn, Zachary; Kennedy, Rosemary; Liber, Alex C.; Stoklosa, Michal; Henson, Rosemarie; Douglas, Clifford E.; Drope, Jacqui (2017). "Key issues surrounding the health impacts of electronic nicotine delivery systems (ENDS) and other sources of nicotine". CA: A Cancer Journal for Clinicians. 67 (6): 449–471. doi: 10.3322/caac.21413. ISSN 0007-9235. PMID 28961314. S2CID 32928770. The physical effects on users are not yet known. [107] The emissions of IQOS are considered to be smoke by independent researchers, and were called smoke by Phillip Morris researchers until 2016. [108] The emissions generated by IQOS contain the identical harmful constituents as tobacco cigarette smoke, including volatile organic compounds at comparable levels to cigarette smoke, polycyclic aromatic hydrocarbons, and carbon monoxide. [3] Each of these substances, on the basis of rigorous research of cigarette smoke, are known to result in significant harms to health. [3] According to Netherlands National Institute for Public Health and the Environment, IQOS is "harmful to health, but probably less harmful than smoking tobacco cigarettes". [109]

a b c Górski, Paweł (2019). "E-cigarettes or heat-not-burn tobacco products — advantages or disadvantages for the lungs of smokers". Advances in Respiratory Medicine. 87 (2): 123–134. doi: 10.5603/ARM.2019.0020. ISSN 2543-6031. PMID 31038725. Forster, Mark; Liu, Chuan; Duke, Martin G; McAdam, Kevin G; Proctor, Christopher J (2015). "An experimental method to study emissions from heated tobacco between 100-200°C". Chemistry Central Journal. 9 (1): 20. doi: 10.1186/s13065-015-0096-1. ISSN 1752-153X. PMC 4418098. PMID 25941536.

najvažnija mana Glo cigareta (kao i ostalih uređaja za zagrevanje duvana) jeste potencijalno povišen nivo jedinjenja koja se kod tradicionalnih cigareta nalaze u znatno manjim količinama, uprkos tome što Glo cigarete svakako imaju manje procente onih drugih štetnih i kancerogenih jedinjenja u odnosu na tradicionalne. To znači da su jedinjenja koja su kod ovih cigareta u većim količinama, takođe štetna po organizam, iako ne ispuštaju onaj čitav standardni spektar kancerogenih jedinjenja koji ispuštaju tradicionalne cigarete; Uranaka, Taiga; Ando, Ritsuko (22 October 2018). "Philip Morris Aims to Revive Japan Sales With Cheaper Heat-Not-Burn Tobacco". U.S. News & World Report. Normally I like menthol flavor, Neo Electric Greencomes with a touch of peppermint, they are not the same as HEETS Turquoise, andtogether with the strange tasteof burnt paper, they didn'timpress me. Electric Yellow is clearly citrus flavored, also not good enough for me, but it can be very different from HEETS and someone might find that appealing. I liked the most Navy Blue, by far, it smells like good tobacco, but soon the described disgusting aftertaste comes. The full results, which were published in Internal and Emergency Medicine, build upon the favourable changes reported at three and six months. The improvements observed were sustained over the 12 months of the study, adding to the weight of evidence that supports glo as a less risky* alternative for adult smokers who would not otherwise quit.In years leading up to 2018, increased tobacco control measures have directed the tobacco industry to develop alternative tobacco products, such as HTPs. [11] There has been a global decline in tobacco consumption that, if continued, will negatively impact the tobacco industry's profits, which has forced the industry to invent and market new products like HTPs. [43] The introduction of HTPs may also have been a response to the growing popularity of e-cigarettes beginning around 2007 after independent companies introduced them before major multinational tobacco companies entered the e-cigarettes market. [43]