In about 1722 he bought a property later known as Dial House, next door to the church of St Mary's, Twickenham, where he either rebuilt, or converted and extended, the buildings already there. He and his two younger brothers lived in relative poverty from 1800 to 1807 at Highshot House, Crown Road; the house was demolished in 1927. During the 18th and 19th centuries, a number of fine houses were built and Twickenham became a popular place of residence for people of "fashion and distinction". There was a high-profile murder on 19 August 2004, when French woman Amelie Delagrange (aged 22) died in hospital after being found with a serious head injury (caused by battery) in the Twickenham Green area. Anglo-Welsh Cup, Heineken Cup and Champions Cup finals have been held here, and the stadium also hosts The Varsity Match between Oxford and Cambridge, the English schools' Daily Mail Cup Final and the Army Navy Match, which forms the culmination of the annual Inter-Services Competition.

The land is fertile and was home to numerous market gardens before housing became the predominant land use with the coming on the railways in the mid nineteenth century.It appears that Twickenham had a pest house in the 17th century, although the location is not known.

In 1937, Middlesex County Council approved a scheme submitted by Twickenham Borough Council to widen Rugby Road due to it being inadequate for traffic. The manor had belonged to Ælfgār, Earl of Mercia in the time of Edward the Confessor, but was granted to Walter de Saint-Valery (Waleric) by William I of England after the Norman Conquest of England in 1066.From 1888 the area was administered jointly between the newly formed Middlesex County Council and the Twickenham Local Government District board, which had been established with the passing of the Local Government Act 1858. Conveniently located beside the train station, it's also a great base if you want access to the sights, restaurants and bars of central London. In 1932, a new West Stand was completed, providing offices for the RFU, who made the ground their home. In terms of ethnicity (as of 2011 census), the majority of people in all four wards identified themselves as White British, ranging between 71% of the population in Twickenham Riverside to 78% in South Twickenham.

The sundial on the façade carries the date 1726, possibly the time when the new building was finished. It hosts the annual London leg of the World Rugby Sevens Series, the Cup (championship) final and third-place match of the annual London leg of the World Rugby Women's Sevens Series, and the domestic Middlesex Sevens competition. The great estate of Cambridge Park, home of Richard Owen Cambridge, the 18th-century satirical poet, was located here. Katie Edith Gliddon (1883–1967), watercolour artist and militant suffragette, was born in Twickenham. The final two games of the agreement were played in 2017, with matchups announced on 13 December 2016.The Twickenham constituency in the UK Parliament includes the towns of Twickenham, St Margarets, Whitton, Teddington, Hampton, Fulwell, Hampton Hill and Hampton Wick. From 1815 to 1817 Louis Philippe leased a house on the Twickenham riverside and gave it the name Orleans House.

Before this, access was by means of a hand-operated ferry that was hauled across using a chain on the riverbed. Tony Blair, former UK Prime Minister, lived in a house in Twickenham in 1972, which he rented from a member of the Vineyard Church in Richmond, and used the Vineyard's crypt every Sunday for promotional events. The Stones also played two shows at Twickenham in August and September 2003, the first of which was used as their stadium concert disc for the 2003 DVD Four Flicks.

Due to train works taking place near to the hotel, some external noise may be heard at night and early in the morning until late 2021. The Twickenham crowd had only seen one England try in the previous two years, and at half-time the team were 0–3 down against Ireland. Twickenham Stadium Tours are also available through the Museum and run four times per day (Tuesday to Saturday) and twice on Sundays.