Vitamin B6 may play a role in improving brain function and preventing Alzheimer’s disease, but the research is conflicting.

Harris SA, Folkers K (April 1939). "Synthetic vitamin B6". Science. 89 (2311): 347. Bibcode: 1939Sci....89..347H. doi: 10.1126/science.89.2311.347. PMID 17788439. Another study found that taking 75 mg of vitamin B6 daily during pregnancy decreased symptoms of anemia in 56 pregnant women who were unresponsive to treatment with iron ( 20). Another study compared the impact of ginger and vitamin B6 on reducing episodes of nausea and vomiting in 126 pregnant women. The results showed that taking 75 mg of B6 each day decreased nausea and vomiting symptoms by 31% after four days ( 29). Johansson, M; Relton, C; Ueland, PM; Vollset, SE; Midttun, Ø (June 2010). "Serum B Vitamin Levels and Risk of Lung Cancer". JAMA. 303 (23): 2377–85. doi: 10.1001/jama.2010.808. ISSN 0098-7484. PMID 20551408.This is likely due to the role of B6 in decreasing elevated homocysteine levels associated with several disease processes, including heart disease ( 31, 32, 33).

The US National Academy of Medicine updated Dietary Reference Intakes for many vitamins in 1998. Recommended Dietary Allowances (RDAs), expressed as milligrams per day, increase with age from 1.2 to 1.5mg/day for women and from 1.3 to 1.7mg/day for men. The RDA for pregnancy is 1.9mg/day, for lactation, 2.0mg/day. For children ages 1–13 years the RDA increases with age from 0.5 to 1.0mg/day. As for safety, Tolerable upper intake levels (ULs) for vitamins and minerals are identified when evidence is sufficient. In the case of vitamin B 6 the adult UL is set at 100mg/day. [4] a b c d Ueland PM, Ulvik A, Rios-Avila L, Midttun Ø, Gregory JF (2015). "Direct and Functional Biomarkers of Vitamin B6 Status". Annu Rev Nutr. 35: 33–70. doi: 10.1146/annurev-nutr-071714-034330. PMC 5988249. PMID 25974692.

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More research that looks at the effect of vitamin B6 alone on homocysteine levels and brain function is needed to better understand the role of this vitamin in improving brain health. a b c d e f g h i j k l m Institute of Medicine (1998). "Vitamin B 6". Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: The National Academies Press. pp.150–195. doi: 10.17226/6015. ISBN 978-0-309-06554-2. LCCN 00028380. OCLC 475527045. PMID 23193625. While these results are promising, they’re limited by small sample size and short duration. More research on the safety and effectiveness of vitamin B6 in improving PMS symptoms is needed before recommendations can be made ( 25). One study in 250 older adults found that deficient blood levels of vitamin B6 doubled the likelihood of depression ( 9).

a b c Bachmann T, Rychlik M (August 2018). "Synthesis of [13C₃]-B6 Vitamers Labelled at Three Consecutive Positions Starting from [13C₃]-Propionic Acid". Molecules. 23 (9). doi: 10.3390/molecules23092117. PMC 6225105. PMID 30142892.

Ahmad I, Mirza T, Qadeer K, Nazim U, Vaid FH (September 2013). "Vitamin B6: deficiency diseases and methods of analysis". Pak J Pharm Sci. 26 (5): 1057–69. PMID 24035968. Zou E, Shi X, Zhang G, Li Z, Jin C, Su W (November 2013). "Improved "Oxazole" Method for the Practical and Efficient Preparation of Pyridoxine Hydrochloride (Vitamin B 6)". Org Process Res Dev. 17 (12): 1498–502. doi: 10.1021/op4001687.

In infants, a deficiency in vitamin B 6 can lead to irritability, abnormally acute hearing, and convulsive seizures. [1] Yang J, Li H, Deng H, Wang Z (2018). "Association of One-Carbon Metabolism-Related Vitamins (Folate, B6, B12), Homocysteine and Methionine With the Risk of Lung Cancer: Systematic Review and Meta-Analysis". Front Oncol. 8: 493. doi: 10.3389/fonc.2018.00493. PMC 6220054. PMID 30430082.

4. Note when using the drug Magne B6

The classic clinical syndrome for vitamin B 6 deficiency is a seborrhoeic dermatitis-like eruption, atrophic glossitis with ulceration, angular cheilitis, conjunctivitis, intertrigo, abnormal electroencephalograms, microcytic anemia (due to impaired heme synthesis), and neurological symptoms of somnolence, confusion, depression, and neuropathy (due to impaired sphingosine synthesis). [1] Researchers suspect that B6 helps with emotional symptoms related to PMS due to its role in creating neurotransmitters that regulate mood. a b c d e f g h Da Silva VR, Gregory III JF (2020). "Vitamin B6". In BP Marriott, DF Birt, VA Stallings, AA Yates (eds.). Present Knowledge in Nutrition, Eleventh Edition. London, United Kingdom: Academic Press (Elsevier). pp.225–38. ISBN 978-0-323-66162-1.