One of the most talked-about benefits of Urolithin A is its potential to support muscle health. As we age, our muscles naturally experience a decline in mass and function. Urolithin A, however, may help counteract this process by promoting the growth of new, healthy mitochondria—the energy powerhouses of our cells. This mitochondrial rejuvenation can lead to improved muscle strength and endurance, making it an appealing option for athletes and fitness enthusiasts looking to optimize their performance. 2. Boosted Cellular Autophagy:

Urolithin A (UA) is produced by gut microflora from foods rich in ellagitannins. UA has been shown to improve mitochondrial health preclinically and in humans. Not everyone has a microbiome capable of producing UA, making supplementation with UA an appealing strategy. Objective Are endorsed by healthcare professionals: Some brands collaborate with healthcare experts who can vouch for the quality and effectiveness of their products. Digestive Aids: To mitigate potential gastrointestinal discomfort, some supplements include digestive enzymes or probiotics to promote gut health. The Best or Nothing (90% Ellagic Acid) – Higher the Ellagic Acid, the more value and benefits. It’s the main active compound best known for giving pomegranate its health-promoting benefits. Each 1,200mg serving of our extract gives you a minimum of 1,080mg of ellagic acid, making this one of the most potent pomegranate supplements available to buy worldwide. These potent beneficial effects were observed in different organisms, including C. elegans​, mammalian cells, rodents, and several human clinical trials.

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Toney AM, Fan R, Xian Y, Chaidez V, Ramer-Tait AE, Chung S, et al. a gut metabolite, improves insulin sensitivity through augmentation of mitochondrial function and biogenesis. Obes (Silver Spring). 2019;27:612–20. As mitophagy become less effective in the ageing body, pressures on cellular health increase significantly. Age-related problems known to be the result of dysfunctioning mitochondria include cellular senescence (the accrual of so-called zombie cells), widespread chronic inflammation and decreases in stem cell production tied directly to poorly functioning mitochondria. Each of these issues further contribute to the rate at which we age. A total of 600 human plasma samples were analyzed from the study (i.e., six samples per subjects with three time points per intervention: T0, T6 hours, and T24 hours) over different batches. Each batch included eight calibration samples, at least two blank samples, one double blank plasma sample, as well as three different quality control samples in duplicate. The inter-batch precision was between 3.1 and 12.3%, whereas the inter-batch accuracy was in the range from 96.6 to 99.3% of nominal concentration. Measurements were performed according to the FDA Guidance for Industry and EMA guidelines on bioanalytical method validation as previously described [ 10]. The quantification of UA and its metabolites, i.e., UA glucuronide and UA sulfate in plasma, was performed by column separation with reverse phase chromatography using an Agilent 1200 HPLC system (Agilent Technologies, Waldbronn, Germany) followed by detection with a TSQ Vantage triple-stage quadropole MS/MS (ThermoFisher Scientific, San Jose, CA, USA) in the selected reaction mode. The plasma samples were diluted with 200 µL water containing 0.1% formic acid, and thereafter fortified with internal standard. A solid-phase extraction with a Bond-Elut focus plate (Agilent Technologies, Waldbronn, Germany) using water as washing solvent and MeOH as elution solvent was used for sample cleanup, and after elution the extraction solvent was evaporated. Subsequently, the sample was reconstituted in 200 µL of a water/methanol mixture (1/1, v/v) and 50 µL was injected into the HPLC MS/MS system. Separation was achieved using a C18 reverse phase column (YMC Co, Ltd., Kyoto, Japan). For the measurements of parent UA in plasma, a validated method was developed. Analysis and quantification were performed using a characterized reference sample of synthesized UA, as the reference item, as well as labeled 13C6 UA, as an internal standard. For the preparation of the internal standard solution 13C6 UA was dissolved in acetonitrile/dimethylsulfoxide (1/1, v/v) to a concentration of 1.00 mg/mL and subsequently diluted to 100,000 ng/mL. Further dilution to a concentration of 2500 ng/mL was done in methanol. In case signal interference compromised the quantification of the analyte and/or the internal standard, the sample was repeated (if sufficient sample volume was available). The concentration of the repeated analysis was reported in case of the absence of the interfering signal. Otherwise, no value was reported for that sample. For quality control in general, 10% of the samples were reanalyzed. Repeat samples were chosen randomly by the analyzing laboratory from the samples belonging to the different study interventions. To measure the levels of UA glucuronide in both plasma and in human whole blood collected in DBS validated methods were developed for each of these matrixes. Analysis and quantification of UA glucuronide was performed for both of these matrixes using a synthesized reference sample consisting of and equal mix of the two isoforms of UA glucuronide as the reference item, as well as labeled 13C6 UA glucuronide as an internal standard. The measurement of UA sulfate in plasma was performed using a validated method, using a characterized reference sample of synthesized UA sulfate as the reference item, as well as labeled 13C6 UA sulfate as an internal standard. The limit of quantification in plasma was 5.00 pg/ml for parent UA and 5.00 ng/ml for both the UA glucuronide and UA sulfate its metabolites. An analytical method to determine UA glucuronide in human whole blood collected by DBS using liquid chromatography coupled to mass spectrometry was also developed and validated. The limit of quantification for UA glucuronide in human DBS samples (6-mm spots) range was 5.00–5000 ng/mL for the analysis of human DBS samples. The quantification of UA glucuronide was performed by column separation with reversed phase liquid chromatography followed by detection with triple-stage quadrupole MS/MS in the selected reaction monitoring mode. The concentration of the analytes was calculated using the internal standardization method. The acquisition and processing of data was performed using LCquan version 2.5.6 and Xcalibur version 2.0.7 (Thermo Fisher Scientific, San Jose, CA, USA). Quantification of ellagic acid, punicalagins, and UA in commercial grade food products and dietary supplements What they found instead was that pomegranate does legitimately have some health benefits. Those health benefits come from urolithin, which is found in high levels deep within the flesh of the plump, pink fruit. Researchers discovered that this one molecule can have powerful anti-aging effects. mental health support. Among nootropic supplements, uridine monophosphate stands out for its effect on memory and anxiety symptoms. More than most nootropic brain supplements, uridine actively interacts with neurons. Thus, supplemental intake of uridine helps improve memory capacity and speed.

Supplemental urolithin A has been shown in animal tests and molecular studies of humans to stimulate mitophagy, a process that Marcinek explained as “mitochondrial quality control.” The dosage of Urolithin A may vary depending on your health and fitness goals. If you’re primarily interested in the potential muscle-enhancing benefits, you might opt for a higher dosage within the recommended range. On the other hand, if you’re aiming to support general wellness and cellular health, a lower dose may suffice. We don't see Mitopure as a substitute or replacement, but as complimentary to physical exercise and caloric restriction.Their mainstay product “Mitopure”, is a Urolithin A supplement, brought to market in the culmination of more than ten years of scientific work, including capstone clinical trials in human subjects. Urolithin A is a type of phytonutrient produced by ellagitannins’ metabolism. This compound has been shown to have many potential health benefits, including preventing or improving conditions like Parkinson’s disease, Alzheimer’s disease, heart disease, and cancer. While more research is needed to confirm these effects, urolithin A supplements may be a promising way to improve your health. If you’re looking for a urolithin A supplement, choose one that is high quality and free of contaminants.