Manuscripts of Pseudo-Apuleius's 5th-century work from the 10th and 11th centuries refer to the use of wild poppy Papaver agreste or Papaver rhoeas (identified as P. silvaticum) instead of P. somniferum for inducing sleep and relieving pain. [27] a b Aurin, Marcus (January 1, 2000). "Chasing the Dragon: The Cultural Metamorphosis of Opium in the United States, 1825–1935". Medical Anthropology Quarterly. 14 (3): 414–441. doi: 10.1525/maq.2000.14.3.414. JSTOR 649506. PMID 11036586. Before the 1920s, regulation in Britain was controlled by pharmacists. Pharmacists who were found to have prescribed opium for illegitimate uses and anyone found to have sold opium without proper qualifications would be prosecuted. [94] With the passing of the Rolleston Act in Britain in 1926, doctors were allowed to prescribe opiates such as morphine and heroin if they believed their patients demonstrated a medical need. Because addiction was viewed as a medical problem rather than an indulgence, doctors were permitted to allow patients to wean themselves off opiates rather than cutting off any opiate use altogether. [95] The passing of the Rolleston Act put the control of opium use in the hands of medical doctors instead of pharmacists. Later in the 20th century, addiction to opiates, especially heroin in young people, continued to rise and so the sale and prescription of opiates was limited to doctors in treatment centers. If these doctors were found to be prescribing opiates without just cause, then they could lose their license to practice or prescribe drugs. [95] Paul Harris in Peshawar (November 25, 2001). "Victorious warlords set to open the opium floodgates". London: Observer.guardian.co.uk . Retrieved March 21, 2010. The process continued until 1817, when Sertürner published his results after thirteen years of research and a nearly disastrous trial on himself and three boys. [102] The great advantage of purified morphine was that a patient could be treated with a known dose—whereas with raw plant material, as Gabriel Fallopius once lamented, "if soporifics are weak they do not help; if they are strong they are exceedingly dangerous."

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John Richards (May 23, 2001). "Opium and the British Indian Empire" . Retrieved September 24, 2007. Santella, Thomas M.; Triggle, D. J. (2009). Opium. Facts On File, Incorporated. p.8. ISBN 9781438102139.The standard medical use of opium persisted well into the 19th century. US president William Henry Harrison was treated with opium in 1841, and in the American Civil War, the Union Army used 175,000lb (80,000kg) of opium tincture and powder and about 500,000 opium pills. [1] During this time of popularity, users called opium "God's Own Medicine". [36] a b c d e f g Dikotter, Frank (2004). Narcotic Culture: A History of Drugs in China. Hurst. p.3. ISBN 978-0226149059. The first known cultivation of opium poppies was in Mesopotamia, approximately 3400 BCE, by Sumerians, who called the plant hul gil, the "joy plant". [11] [12] Tablets found at Nippur, a Sumerian spiritual center south of Baghdad, described the collection of poppy juice in the morning and its use in production of opium. [1] Cultivation continued in the Middle East by the Assyrians, who also collected poppy juice in the morning after scoring the pods with an iron scoop; they called the juice aratpa-pal, possibly the root of Papaver. [13] Opium production continued under the Babylonians and Egyptians. William Muir (1875), The opium revenue: Sir William Muir's minute and other extracts from papers published by the Calcutta government; also extracts from parliamentary papers (1sted.), London: The Anglo-Oriental Society for the Suppression of the Opium Trade, p.30, Wikidata Q19095804

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Simon O'Dochartaigh. "HON Mother & Child Glossary, Meconium". hon.ch. Archived from the original on May 1, 2021 . Retrieved April 4, 2016. Alfred W. McCoy (1972). "The politics of heroin in Southeast Asia". Archived from the original on October 7, 2007 . Retrieved September 24, 2007. Robinson SL, Rowbotham DJ, Smith G (July 1991). "Morphine compared with diamorphine. A comparison of dose requirements and side-effects after hip surgery". Anaesthesia. 46 (7): 538–40. doi: 10.1111/j.1365-2044.1991.tb09650.x. PMID 1862890. S2CID 35289009. I often wear Zara fragrances and find them suitable for special occasions, despite being just a fraction of the price of designer fragrances. They are long lasting and many, including Gardenia, have great sillage and projection.

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Derks, Hans: History of the Opium Problem: The Assault on the East, ca. 1600–1950. Sinica Leidensia, 105. Leiden: Brill, 2012. ISSN 0169-9563. ISBN 978-90-04-22158-1

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Anil Aggrawal (1995). "CHAPTER 2: THE STORY OF OPIUM". Narcotic Drugs. New Delhi: National Book Trust. ISBN 978-81-237-1383-0. Michot, Yahya. L’opium et le café. Traduction d’un texte arabe anonyme et exploration de l'opiophagie ottomane (Beirut: Albouraq, 2008) ISBN 978-2-84161-397-7 MacPherson, Duncan (1843). Two years in China. Narrative of the Chinese expedition, from its formation in April, 1840, to the treaty of peace in August, 1842. London, Saunders. Sawynok J (January 1986). "The therapeutic use of heroin: a review of the pharmacological literature". Canadian Journal of Physiology and Pharmacology. 64 (1): 1–6. doi: 10.1139/y86-001. PMID 2420426. Smith RD (October 1980). "Avicenna and the Canon of Medicine: a millennial tribute". The Western Journal of Medicine. 133 (4): 367–70. PMC 1272342. PMID 7051568.

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a b c d Philip Robson (1999). Forbidden Drugs. Oxford University Press. p. 161. ISBN 978-0-19-262955-5. a b Rewriting history, A response to the 2008 World Drug Report, Transnational Institute, June 2008 Opium prohibition in China began in 1729, yet was followed by nearly two centuries of increasing opium use. A massive destruction of opium by an emissary of the Chinese Daoguang Emperor in an attempt to stop opium smuggling by the British led to the First Opium War (1839–1842), in which Britain defeated China. After 1860, opium use continued to increase with widespread domestic production in China. By 1905, an estimated 25 percent of the male population were regular consumers of the drug. Recreational use of opium elsewhere in the world remained rare into late in the 19th century, as indicated by ambivalent reports of opium usage. [44] In 1906, 41,000 tons were produced, but because 39,000 tons of that year's opium were consumed in China, overall usage in the rest of the world was much lower. [48] These figures from 1906 have been criticized as overestimates. [49] A Chinese opium house; photographed in 1902 Hayatbakhsh M, Oghabian Z, Conlon E, Nakhaee S, Amirabadizadeh A, Zahedi M, et al. Lead poisoning among opium users in Iran: an emerging health hazard. Substance Abuse Treatment, Prevention, and Policy. 2017;12(43).

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Benjamin Pui-Nin Mo & E. Leong Way (October 1, 1966). "An Assessment Of Inhalation As A Mode Of Administration Of Heroin By Addicts". Journal of Pharmacology and Experimental Therapeutics. 154 (1): 142–151. PMID 5924312 . Retrieved June 6, 2007. Parrott A, Morinan A, Moss M, Scholey A. Understanding drugs and behaviour. West Sussex: John Wiley & Sons Ltd; 2004. Opium and alcohol/benzodiazepines/ketamine/GHB: can increase sedation and lead to unconsciousness, choking on vomit, and possible death. 6,7 Extensive textual and pictorial sources also show that poppy cultivation and opium consumption were widespread in Safavid Iran [42] and Mughal India. [43] England [ edit ]Auerbach, Sascha. Race, Law and 'The Chinese Puzzle' in Imperial Britain. New York: Palgrave-Macmillan Press, 2009. El Zahrawi – Father Of Surgery". Archived from the original on September 27, 2007 . Retrieved May 4, 2007. In Eastern culture, opium is more commonly used in the form of paregoric to treat diarrhea. This is a weaker solution than laudanum, an alcoholic tincture which was prevalently used as a pain medication and sleeping aid. Tincture of opium has been prescribed for, among other things, severe diarrhea. [148] Taken thirty minutes prior to meals, it significantly slows intestinal motility, giving the intestines greater time to absorb fluid in the stool.