Tricyclic antidepressants (e.g. amitriptyline): may increase the risk of cardiovascular side effects with phenylephrine (see section 4.3). LEMSIP MAX DAY & NIGHT COLD & FLU RELIEF CAPSULES: Each day capsule contains Paracetamol 500 mg, Caffeine 25 mg, Phenylephrine LEMSIP MAX ALL IN ONE LIQUID: Paracetamol 1000 mg, Guaifenesin 200mg, Phenylephrine hydrochloride 12.18mg,

Paracetamol: Paracetamol is absorbed readily after taking the product and is detected in the plasma within 5 minutes or oral dosing. The pharmacokinetic model shows faster absorption seen over the first 30 minutes for the product compared to a standard does of two paracetamol tablets, however, the overall extent of absorption of both products remains the same. Actual mean plasma levels at each time point show the time to achieve a level of 5 µg/ml is less than 14 minutes, compared to 22 minutes for standard paracetamol tablets; the speed to achieve 10 µg/ml being 19 minutes versus 30 minutes. Sympathomimetic amines: concomitant use of phenylephrine with other sympathomimetic amines can increase the risk of cardiovascular side effects. The median time to maximum plasma concentration (t max) was 35 minutes which was the same as a standard dose of two tablets of 500 mg paracetamol. Epidemiological studies in human pregnancy have shown no ill effects due to paracetamol used in the recommended dosage.

Due to its aspartame content this medicinal product should not be given to patients with phenylketonuria. contains Paracetamol 500 mg, Guaifenesin 100 mg Phenylephrine hydrochloride 6.1 mg Indications: For the relief of symptoms of colds and This medicinal product contains 118.39 mg sodium per dose, equivalent to 5.9 % of the WHO recommended maximum daily intake for sodium.

In a study of healthy controls fasted overnight the T max for an equivalent product compared to two tablets of standard paracetamol was 20 minutes versus 35 minutes (p=0.0865). However, the speed to achieve 10 μg/ml for the product was faster than a standard paracetamol (17 minutes versus 30 minutes). symptoms associated with the common cold and influenza, including relief of aches and pains, sore throat, headache, fatigue and Paracetamol and phenylephrine/ pseudoephedrine work in two ways to relieve symptoms. The exact way paracetamol works is still unknown but it is a well established and safe treatment for mild to moderate pain. The decongestants reduce swelling of the sinus passages of the nose. This opens up the airways and relieves pressure build-ups which can cause pain. What alternatives are there for Lemsip? Patients with rare hereditary problems of fructose intolerance, glucose- galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine.Monoamine oxidase inhibitors (including moclobemide) (MAOIs): Hypertensive interactions occur between sympathomimetic amines such as phenylephrine and monoamine oxidase inhibitors (see section 4.3). Healthcare (UK) Ltd, Hull, HU8 7DS. Information about this product, including adverse reactions, precautions, contra-indications,

Immediate medical advice should be sought in the event of an overdose, even if the patient feels well because of the risk of delayed serious liver damage The maximum daily dose of this product is equivalent to 23.7 % of the WHO recommended maximum daily intake for sodium. The maximum daily dose of this product is equivalent to 25.7 % of the WHO recommended maximum daily intake for sodium.Directions How to take: For oral use. Pour one sachet of powder into a mug and fill with hot, but not boiling, water. Stir until dissolved. If preferred, sweeten to taste with sugar, honey or your usual sweetener. How much to take: Adults, the elderly and children aged 16 years and over: 1 sachet every 4-6 hours. Do not take more than 4 sachets in 24 hours. Do not give to children under 16 years of age. Do not take more medicine than the label tells you to. If you do not get better, talk to your doctor. Do not take if: you are allergic to any ingredient, you have heart disease, high blood pressure, overactive thyroid, an enlarged prostate, or if you are taking or have taken MAOI's (antidepressants) within 14 days or other sympathomimetic, decongestants. influenza, including the relief of aches and pains, sore throat, headache, nasal congestion, lowering of temperature and chesty coughs Patients with rare hereditary problems of galactose intolerance, the total lactase deficiency or glucose-galactose malabsorption should not take this medicine. Phenylephrine should be used with care in patients with closed angle glaucoma and prostatic enlargement.

Immediate medical advice should be sought in the event of an overdose, even if the patient feels well because of the risk of delayed serious liver damage (see section 4.9). Treatment with activated charcoal should be considered if the overdose has been taken within 1 hour. Plasma paracetamol concentration should be measured at 4 hours or later after ingestion (earlier concentrations are unreliable). Treatment with N-acetylcysteine may be used up to 24 hours after ingestion of paracetamol, however, the maximum protective effect is obtained up to 8 hours post-ingestion. The effectiveness of the antidote declines sharply after this time. If required the patient should be given intravenous N-acetylcysteine, in line with the established dosage schedule. If vomiting is not a problem, oral methionine may be a suitable alternative for remote areas, outside hospital. Management of patients who present with serious hepatic dysfunction beyond 24 hours from ingestion should be discussed with the NPIS or a liver unit. Indications: For the relief of symptoms associated with the common cold and influenza, including relief of aches and pains, sore throat,Paracetamol: Paracetamol is absorbed rapidly and completely mainly from the small intestine, producing peak plasma levels after 15-20 minutes following oral dosing. The systemic availability is subject to first-pass metabolism and varies with dose between 70% and 90%. The drug is rapidly and widely distributed throughout the body and is eliminated from plasma with a T ½ of approximately 2 hours. The major metabolites are glucuronide and sulphate conjugates (>80%) which are excreted in urine. The product should not be used during pregnancy unless recommended by a healthcare professional (see section 4.6). Sympathomimetic agents: Concomitant use of phenylephrine with other sympathomimetic amines can increase the risk of hypertension and other cardiovascular side effects (see section 4.3). Information about this product, including adverse reactions, precautions, contra-indications, and method of use can be found at: Cetylpyridinium Chloride 3.0 mg /20ml dose Indications: Short term symptomatic relief of the symptoms of colds and flu, including