Rodriguez and Deke Shaw were tasked with retrieving a device from Niles Lindmore and deliver it to Phil Coulson, who was on a mission with Daniel Sousa. Rodriguez noticed that Shaw was quiet during the drive, and they talked about how incredibly sexist and racist the past was, which Rodriguez told Shaw got better, only slowly. Shaw noted that they couldn't make any big changes, due to messing up the timeline, which made Rodriguez feel like they were just "Agents of Status Quo."

Hey, I just stopped the bullets but you dropped them down." ―Yo-Yo Rodriguez and Joey Gutierrez [src] When Rodriguez came across Melinda May, she was told that whether she made the right decision was up to her to decide, and that she had to make peace with it and with how people would from see her. Upon learning that Johnson was finding a way to save Coulson, Rodriguez revealed how she hd spoke with herself in the future, who said saving Coulson was what caused them to fail. May disagreed with this, but Rodriguez was sure of what she was told, but was interrupted when Coulson realised the aliens had the ability to teleport inside. Upon returning to the Lighthouse, the team were informed by Jemma Simmons that Phil Coulson's condition was worsening and accelerating. Simmons mentioned a possible way to save him, which Rodriguez was against, knowing that it results in their failure. Leo Fitz revealed a way to stop Glenn Talbot, but due to the limited resources, they could only either save Coulson or the world. [50]

So you're okay with the killing, Jaco? How's that strategy working out for you? Save a lot of planets lately?" Jiaying agreed to help Rodriguez, so they began with acupuncture, but Rodriguez did not think it would help her. Jiaying then asked about what was the poison that took her powers, but Rodriguez could not reveal it was an alien bird in the future, so she just said it killed a friend of hers. Rodriguez thanked Jiaying for her help, but when Li held a knife to May, Rodriguez tried to use her powers to save her, only for them to still not work, which was what Li was testing. They decided to finish for the day. While the others went out to investigate the Chronicom's recent actions, Rodriguez and Simmons watched as Enoch treated May in the Healing Pod. Rodriguez questioned if they could trust Enoch as he was not a human, but Simmons assured her they could as he was the reason she was alive. Simmons stated that May would make a full recovery, and then informed Rodriguez that her body was breaking down the Shrike material, and would soon be completely out of her system, much to her relief. And you were a baker. The runt. Is this what your family would've wanted?" ―Yo-Yo Rodriguez and Jaco [src] My heart was beating so fast, I thought someone had put cocaine in my beer." ―Yo-Yo Rodriguez and Flint [src]

You heard all this, and still you couldn't change anything." ― Yo-Yo Rodriguez and Yo-Yo Rodriguez [src] No vamos a usarlas! ¡Estamos asegurándonos de que nadie las use! [8]" ― Joey Gutierrez and Elena Rodriguez [src]This right here... this is how we lose. I could've warned myself about a lot of things – Ruby, Hale, these aliens – but instead, she told me... Instead, she told me, "Coulson is dying, and we need to let him." I'm sorry, sir. I hated keeping this. I owe you so much. You're my family." ―Yo-Yo Rodriguez and Melinda May [src] Rodriguez tried to keep Flint hidden, saying that the Kree only wanted to use him. When the rest of the group found them, Rodriguez revealed to Flint that she was Inhuman, too, and they discussed their plans to go to Earth. Rodriguez told Flint about her own Terrigenesis, but they were found by Grill, who threatened them. At that moment, Flint's geokinesis manifested, so Rodriguez guided him through it, and he ended up killing Grill. [6] As May trained with Rodriguez, she brought up how she detected Damon Keller being attracted to her, and believed it was mutual. Rodriguez denied it, but May encouraged her to embrace it, noting how they shouldn't be alone in life. Rodriguez met up with Keller afterwards to tell him that May was onto them. She decided to take a break from her relationship with Keller, saying it was for herself, and Keller supported her decision. Spy: As Rodriguez went on more missions with S.H.I.E.L.D., she improved at being a spy. She successfully hid her Inhuman nature from her best friends until she was forced to unveil them. Expert Marksman: Rodriguez is a skilled sniper, managing to hit three men at once. She didn't need to use her gun much because of her powers, but when she was temporarily unable to use her powers, she used her gun more.

We did a thorough search for any contaminants, foreign particles, pathogens. Nothing came up. I'm sorry, Elena, but your problem isn't physical. It's in your mind." ― Jiaying to Yo-Yo Rodriguez [src] I killed Ruby for nothing. It didn't matter. It's all happening right now. Everything she told me."But before they could leave, they were reunited with Quake, who informed them that she had led an army of Shrike hosts away from the temple so Melinda May and Sarge could get inside. As the discussed Zephyr One's condition, they informed Quake about Flint's creation, which they argued about, as she claimed he wasn't real, but they told her he was. They were then surprised as a group of Shrike hosts had entered the Zephyr and came after them, forcing them to retreat.

The signal brought them to The Krazy Kanoe, where they were surrounded by armed people, with one of them killing John Garrett immediately. Rodriguez told Phil Coulson she could disarm them all, but he advised against it, and he introduced himself to the people in the room, who were all S.H.I.E.L.D. agents, and they stood down. Brandon Gamble informed them of the 0-8-4s they were asked to bring, but none of them knew what the pieces were for. Rodriguez secured herself in the Quinjet, believing that the pilot was taking her to her assignment in Los Angeles. The pilot told her the flight would only be twenty minutes, leaving her confused as it should take a few hours to get to Los Angeles. Rodriguez asked the pilot why the flight was so short, and he revealed that they were actually going to Baltimore. She realized that May told the pilot where to go, and they gave each other a smile as the Quinjet door closed. [22] Hunting Victor Ramon [ ] Once the ship was full, they were planning on leaving the city, but when they were joined by James Davis, who was dragging Phil Coulson, he revealed that he was not breathing, having not actually taken the Centipede Serum. Rodriguez blamed herself, thinking Coulson listened to her disagreement with saving him. Rodriguez then began doing chest compressions on Coulson, but it wasn't working, so she used her speed to do it as she prayed in Spanish, and successfully revived Coulson.Later, Prabhakar returned for SPIDER-GEDDON (2018), playing a relatively minor role as part of Miles Morales’ Spider-Army. In the end, Prabhakar helped transfer the minds of the Inheritors to the bodies of newborn babies, giving them a chance to be better than they had been in their previous lives. He also returned for the “End of Spider-Verse” arc in SPIDER-MAN (2022), where he helped defeat Shathra, an evil wasp goddess dedicated to killing those with spider-based powers. Cybernetic Enhancement: After losing both her arms to Ruby Hale's Chakram, Rodriguez obtained cybernetic arms which granted her additional powers to complement her natural Inhuman powers. However, since they were repurposed Sleeper Mech arms and were not specifically designed for her, the original arms themselves were initially incompatible with her Inhuman powers; they overloaded her nervous system because they were not designed for extreme speeds. Leo Fitz recalibrated them shortly before the Siege of the Lighthouse, allowing her to use her Inhuman powers. Eventually, Jemma Simmons created new, organic-looking arms designed to help her blend in with the 1930s, specifically designed for her and with simulated nerve endings.